Concomitant Enhancement of B-Cell Mitogenesis and Inhibition of Antibody Synthesis by a Phorbol Ester

Thomas A. Ferguson; Larry A. Fish; C. Stuart Baxter; J. Gabriel Michael

doi:10.3181/00379727-171-41481

Concomitant Enhancement of B-Cell Mitogenesis and Inhibition of Antibody Synthesis by a Phorbol Ester

Thomas A. Ferguson, Larry A. Fish, C. Stuart Baxter, J. Gabriel Michael

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Abstract

12-O-Tetradecaroyl-phorbol-13-acetate (TPA), a potent tumor-promoting agent, was found to enhance proliferation of murine splenic lymphocytes in response to B-cell mitogens, while possessing no mitogenic activity by itself. At the same time, TPA inhibited the B mitogen-induced polyclonal responses as well as antigen-specific antibody responses of cultured murine spleen cells. Our results support the hypothesis that tumor promoters inhibit lymphocyte differentiation.

Original language	English
Pages (from-to)	83-87
Number of pages	5
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	171
Issue number	1
DOIs	https://doi.org/10.3181/00379727-171-41481
State	Published - Oct 1982

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abstract = "12-O-Tetradecaroyl-phorbol-13-acetate (TPA), a potent tumor-promoting agent, was found to enhance proliferation of murine splenic lymphocytes in response to B-cell mitogens, while possessing no mitogenic activity by itself. At the same time, TPA inhibited the B mitogen-induced polyclonal responses as well as antigen-specific antibody responses of cultured murine spleen cells. Our results support the hypothesis that tumor promoters inhibit lymphocyte differentiation.",

author = "Ferguson, {Thomas A.} and Fish, {Larry A.} and Baxter, {C. Stuart} and Michael, {J. Gabriel}",

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AU - Fish, Larry A.

AU - Baxter, C. Stuart

AU - Michael, J. Gabriel

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N2 - 12-O-Tetradecaroyl-phorbol-13-acetate (TPA), a potent tumor-promoting agent, was found to enhance proliferation of murine splenic lymphocytes in response to B-cell mitogens, while possessing no mitogenic activity by itself. At the same time, TPA inhibited the B mitogen-induced polyclonal responses as well as antigen-specific antibody responses of cultured murine spleen cells. Our results support the hypothesis that tumor promoters inhibit lymphocyte differentiation.

AB - 12-O-Tetradecaroyl-phorbol-13-acetate (TPA), a potent tumor-promoting agent, was found to enhance proliferation of murine splenic lymphocytes in response to B-cell mitogens, while possessing no mitogenic activity by itself. At the same time, TPA inhibited the B mitogen-induced polyclonal responses as well as antigen-specific antibody responses of cultured murine spleen cells. Our results support the hypothesis that tumor promoters inhibit lymphocyte differentiation.

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Concomitant Enhancement of B-Cell Mitogenesis and Inhibition of Antibody Synthesis by a Phorbol Ester

Abstract

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