12-O-Tetradecaroyl-phorbol-13-acetate (TPA), a potent tumor-promoting agent, was found to enhance proliferation of murine splenic lymphocytes in response to B-cell mitogens, while possessing no mitogenic activity by itself. At the same time, TPA inhibited the B mitogen-induced polyclonal responses as well as antigen-specific antibody responses of cultured murine spleen cells. Our results support the hypothesis that tumor promoters inhibit lymphocyte differentiation.
|Number of pages||5|
|Journal||Proceedings of the Society for Experimental Biology and Medicine|
|State||Published - Oct 1982|