Concomitant chemotherapy and radiation for the treatment of advanced-stage endometrial cancer

I. Wilkinson-Ryan, P. S. Binder, S. Pourabolghasem, N. Al-Hammadi, K. Fuh, A. Hagemann, P. Thaker, J. Schwarz, P. Grigsby, D. Mutch, M. Powell

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Introduction Ccombination chemotherapy and radiation therapy is used for adjuvant treatment of stage III-IV endometrial cancer. The goal of this study was to review the treatment duration, toxicity, and survival for patients treated with concomitant chemotherapy and radiation. Methods Women with stage III-IV endometrial cancer treated with concurrent chemotherapy and radiation between 2006 and 2013 were included. Toxicities were classified per CTCAE v3.0 and RTOG/EORTC late radiation morbidity scoring. Descriptive statistics were used to quantify treatment and toxicities. Kaplan-Meier method was used to estimate survival. Results Fifty-one patients met our inclusion criteria. Median age was 60 (range 33-85). Thirty-six patients (70.6%) had endometrioid histology, 13 patients (25.5%) had serous, clear cell, or mixed histology, and 2 women (3.9%) had carcinosarcoma. Forty-eight patients had stage III disease and three patients were stage IVB. Mean treatment duration was 107 ± 19 days. Forty-two patients received all planned chemotherapy, and 16 patients required a dose reduction. Thirty-four patients (66.7%) experienced grade 3-4 toxicities, the majority of which were hematologic. There were no deaths related to therapy. Eighty-six percent of patients received leukocyte growth factors, and 25% of patients received a blood transfusion. Seven late grade 3-4 complications occurred: four gastrointestinal and two genitourinary, and one patient had ongoing neuropathy. Median progression-free survival was 42.8 months (range 4.4-81.5 months) and median overall survival was 44.9 months (range 5.1-82.6 months). Three-year overall survival was 80%. Conclusion Concomitant chemotherapy and radiation is an adequately tolerated treatment modality that allows for shorter treatment duration.

Original languageEnglish
Pages (from-to)24-28
Number of pages5
JournalGynecologic oncology
Volume134
Issue number1
DOIs
StatePublished - Jul 2014

Keywords

  • chemoradiation
  • chemotherapy and radiation
  • concomitant chemotherapy and radiation
  • concurrent
  • endometrial cancer

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