Abstract
Background: Effectiveness and toxicity of transcatheter arterial injection of irinotecan-eluting beads (DEBIRI) with and without concurrent capecitabine in pretreated patients with metastatic colorectal cancer (CRC). Patients and Methods: An Institutional Review Boardapproved, multi-institutional registry from 5/2008 to 8/2013 was reviewed. Patients who received DEBIRI with (XDEBIRI) or without (DEBIRI) capecitabine were compared. Results: Twenty-two X-DEBIRI and 149 DEBIRI patients were compared. There was no difference in the two groups with regards to adverse events (p=0.56). During a 3- and 6- month evaluation, the disease control rate (DCR) was similar in both groups. During the 12-month evaluation, there was better DCR in the X-DEBIRI group (p=0.03). Median survival was 13 months in the DEBIRI group and 22 months in the X-DEBIRI group (log-rank test, p=0.217). Conclusion: There is no additional toxicity when adding capecitabine with DEBIRI. Concurrent capecitabine may offer more durable disease control rate compared to DEBIRI-alone. Survival benefit with concurrent capecitabine was not statistically significant but there may be a trend towards improved survival.
Original language | English |
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Pages (from-to) | 7239-7245 |
Number of pages | 7 |
Journal | Anticancer research |
Volume | 34 |
Issue number | 12 |
State | Published - Dec 1 2014 |
Keywords
- Capecitabine
- Chemoembolization
- Drugeluting-beads
- Irinotecan
- Toxicity