Abstract
Subcutaneous fat has emerged as an alternative tissue source for stromal/stem cells in regenerative medicine. Over the past decade, international research efforts have established a wealth of basic science and preclinical evidence regarding the differentiation potential and regenerative properties of both freshly processed, heterogeneous stromal vascular fraction cells and culture expanded, relatively homogeneous adipose-derived stromal/stem cells. the stage has been set for clinicians to translate adipose-derived cells from the bench to the bedside; however, this process will involve "development" steps that fall outside of traditional "hypothesis-driven, mechanism-based'' paradigm. This concise review examines the next stages of the development process for therapeutic applications of adipose-derived cells and highlights the current state of the art regarding clinical trials. It is recommended that the experiments addressing these issues be reported comprehensively in the peer-review literature. This transparency will accelerate the standardization and reproducibility of adipose-derived cell therapies with respect to their efficacy and safety.
| Original language | English |
|---|---|
| Pages (from-to) | 749-754 |
| Number of pages | 6 |
| Journal | STEM CELLS |
| Volume | 29 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 2011 |
Keywords
- Adipogenesis
- Adipose
- Adult stem cells
- Cellular therapy
- Clinical translation
- Current Good Manufacturing Practices
- Stem cell transplantation
- Stromal cells