TY - GEN
T1 - Computer simulation of vestibuloocular reflex motor learning using a realistic cerebellar cortical neuronal network model
AU - Inagaki, Kayichiro
AU - Hirata, Yutaka
AU - Blazquez, Pablo M.
AU - Highstein, Stephen M.
PY - 2008/10/27
Y1 - 2008/10/27
N2 - The vestibuloocular reflex (VOR) is under adaptive control to stabilize our vision during head movements. It has been suggested that the acute VOR motor learning requires long-term depression (LTD) and potentiation (LTP) at the parallel fiber - Purkinje cell synapses in the cerebellar flocculus. We simulated the VOR motor learning basing upon the LTD and LTP using a realistic cerebellar cortical neuronal network model. In this model, LTD and LTP were induced at the parallel fiber - Purkinje cell synapses by the spike timing dependent plasticity rule, which considers the timing of the spike occurrence in the climbing fiber and the parallel fibers innervating the same Purkinje cell. The model was successful to reproduce the changes in eye movement and Purkinje cell simple spike firing modulation during VOR in the dark after low and high gain VOR motor learning.
AB - The vestibuloocular reflex (VOR) is under adaptive control to stabilize our vision during head movements. It has been suggested that the acute VOR motor learning requires long-term depression (LTD) and potentiation (LTP) at the parallel fiber - Purkinje cell synapses in the cerebellar flocculus. We simulated the VOR motor learning basing upon the LTD and LTP using a realistic cerebellar cortical neuronal network model. In this model, LTD and LTP were induced at the parallel fiber - Purkinje cell synapses by the spike timing dependent plasticity rule, which considers the timing of the spike occurrence in the climbing fiber and the parallel fibers innervating the same Purkinje cell. The model was successful to reproduce the changes in eye movement and Purkinje cell simple spike firing modulation during VOR in the dark after low and high gain VOR motor learning.
KW - Long-term depression
KW - Long-term potentiation
KW - Spike neuron model
KW - Spike timing dependent plasticity
KW - VOR motor learning
UR - http://www.scopus.com/inward/record.url?scp=54249120054&partnerID=8YFLogxK
U2 - 10.1007/978-3-540-69158-7_93
DO - 10.1007/978-3-540-69158-7_93
M3 - Conference contribution
AN - SCOPUS:54249120054
SN - 3540691545
SN - 9783540691549
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 902
EP - 912
BT - Neural Information Processing - 14th International Conference, ICONIP 2007, Revised Selected Papers
T2 - 14th International Conference on Neural Information Processing, ICONIP 2007
Y2 - 13 November 2007 through 16 November 2007
ER -