Computer simulation of vestibuloocular reflex motor learning using a realistic cerebellar cortical neuronal network model

Kayichiro Inagaki, Yutaka Hirata, Pablo M. Blazquez, Stephen M. Highstein

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

3 Scopus citations

Abstract

The vestibuloocular reflex (VOR) is under adaptive control to stabilize our vision during head movements. It has been suggested that the acute VOR motor learning requires long-term depression (LTD) and potentiation (LTP) at the parallel fiber - Purkinje cell synapses in the cerebellar flocculus. We simulated the VOR motor learning basing upon the LTD and LTP using a realistic cerebellar cortical neuronal network model. In this model, LTD and LTP were induced at the parallel fiber - Purkinje cell synapses by the spike timing dependent plasticity rule, which considers the timing of the spike occurrence in the climbing fiber and the parallel fibers innervating the same Purkinje cell. The model was successful to reproduce the changes in eye movement and Purkinje cell simple spike firing modulation during VOR in the dark after low and high gain VOR motor learning.

Original languageEnglish
Title of host publicationNeural Information Processing - 14th International Conference, ICONIP 2007, Revised Selected Papers
Pages902-912
Number of pages11
EditionPART 1
DOIs
StatePublished - Oct 27 2008
Event14th International Conference on Neural Information Processing, ICONIP 2007 - Kitakyushu, Japan
Duration: Nov 13 2007Nov 16 2007

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
NumberPART 1
Volume4984 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference14th International Conference on Neural Information Processing, ICONIP 2007
Country/TerritoryJapan
CityKitakyushu
Period11/13/0711/16/07

Keywords

  • Long-term depression
  • Long-term potentiation
  • Spike neuron model
  • Spike timing dependent plasticity
  • VOR motor learning

Fingerprint

Dive into the research topics of 'Computer simulation of vestibuloocular reflex motor learning using a realistic cerebellar cortical neuronal network model'. Together they form a unique fingerprint.

Cite this