Computer-assisted analysis of bioactivity. I. - Active conformation of histamine H1 receptor antagonists

S. Naruto, I. Motoc, G. R. Marshall

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Molecular mechanics and computer graphics studies were performed for seven potent competitive antagonists (commercially available drugs) of histamine H1 receptor. The assumed four point pharmacophore hypothesis was found consistent with the bioactivity and may be useful in guiding the synthesis of new and potent antihistaminics.

Original languageEnglish
Pages (from-to)529-532
Number of pages4
JournalEuropean Journal of Medicinal Chemistry
Volume20
Issue number6
StatePublished - Jan 1 1985

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