Abstract
Molecular mechanics and computer graphics studies were performed for seven potent competitive antagonists (commercially available drugs) of histamine H1 receptor. The assumed four point pharmacophore hypothesis was found consistent with the bioactivity and may be useful in guiding the synthesis of new and potent antihistaminics.
Original language | English |
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Pages (from-to) | 529-532 |
Number of pages | 4 |
Journal | European Journal of Medicinal Chemistry |
Volume | 20 |
Issue number | 6 |
State | Published - Jan 1 1985 |