Computationally restoring the potency of a clinical antibody against Omicron

Tri-lab COVID-19 Consortium; Thomas A. Desautels; Kathryn T. Arrildt; Adam T. Zemla; Edmond Y. Lau; Fangqiang Zhu; Dante Ricci; Stephanie Cronin; Seth J. Zost; Elad Binshtein; Suzanne M. Scheaffer; Bernadeta Dadonaite; Brenden K. Petersen; Taylor B. Engdahl; Elaine Chen; Laura S. Handal; Lynn Hall; John W. Goforth; Denis Vashchenko; Sam Nguyen; Dina R. Weilhammer; Jacky Kai Yin Lo; Bonnee Rubinfeld; Edwin A. Saada; Tracy Weisenberger; Tek Hyung Lee; Bradley Whitener; James B. Case; Alexander Ladd; Mary S. Silva; Rebecca M. Haluska; Emilia A. Grzesiak; Christopher G. Earnhart; Svetlana Hopkins; Thomas W. Bates; Larissa B. Thackray; Brent W. Segelke; Emily Z.Alipio Lyon; Penelope S. Anderson; Aram Avila-Herrera; William F. Bennett; Feliza A. Bourguet; Julian C. Chen; Matthew A. Coleman; Nicole M. Collette; Anastasiia Davis; Byron D. Vannest; Erika J. Fong; Sean Gilmore; Andre R. Goncalves; Sara B. Hall; Brooke Harmon; Wei He; Steven A. Hoang-Phou; Mikel Landajuela; Ted A. Laurence; Tek Hyung Lee; Felipe Leno Da Silva; Chao Liu; Terrel N. Mundhenk; Mariam V. Mohagheghi; Peter R. McIlroy; Le Thanh Mai Pham; Joseph C. Sanchez; Anupama Sinha; Emilia A. Solomon; Nicholas Watkins; Jiachen Yang; Congwang Ye; Boya Zhang; Antonietta Maria Lillo; Shivshankar Sundaram; Jesse D. Bloom; Michael S. Diamond; James E. Crowe; Robert H. Carnahan; Daniel M. Faissol

doi:10.1038/s41586-024-07385-1

Computationally restoring the potency of a clinical antibody against Omicron

Tri-lab COVID-19 Consortium, Thomas A. Desautels, Kathryn T. Arrildt, Adam T. Zemla, Edmond Y. Lau, Fangqiang Zhu, Dante Ricci, Stephanie Cronin, Seth J. Zost, Elad Binshtein, Suzanne M. Scheaffer, Bernadeta Dadonaite, Brenden K. Petersen, Taylor B. Engdahl, Elaine Chen, Laura S. Handal, Lynn Hall, John W. Goforth, Denis Vashchenko, Sam NguyenDina R. Weilhammer, Jacky Kai Yin Lo, Bonnee Rubinfeld, Edwin A. Saada, Tracy Weisenberger, Tek Hyung Lee, Bradley Whitener, James B. Case, Alexander Ladd, Mary S. Silva, Rebecca M. Haluska, Emilia A. Grzesiak, Christopher G. Earnhart, Svetlana Hopkins, Thomas W. Bates, Larissa B. Thackray, Brent W. Segelke, Emily Z.Alipio Lyon, Penelope S. Anderson, Aram Avila-Herrera, William F. Bennett, Feliza A. Bourguet, Julian C. Chen, Matthew A. Coleman, Nicole M. Collette, Anastasiia Davis, Byron D. Vannest, Erika J. Fong, Sean Gilmore, Andre R. Goncalves, Sara B. Hall, Brooke Harmon, Wei He, Steven A. Hoang-Phou, Mikel Landajuela, Ted A. Laurence, Tek Hyung Lee, Felipe Leno Da Silva, Chao Liu, Terrel N. Mundhenk, Mariam V. Mohagheghi, Peter R. McIlroy, Le Thanh Mai Pham, Joseph C. Sanchez, Anupama Sinha, Emilia A. Solomon, Nicholas Watkins, Jiachen Yang, Congwang Ye, Boya Zhang, Antonietta Maria Lillo, Shivshankar Sundaram, Jesse D. Bloom, Michael S. Diamond, James E. Crowe, Robert H. Carnahan, Daniel M. Faissol

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

By demonstrating a computational approach to restore the clinical efficacy of a COVID-19 antibody, the potential to rapidly update clinical antibodies is explored.

Original language	English
Pages (from-to)	878-885
Number of pages	8
Journal	Nature
Volume	629
Issue number	8013
DOIs	https://doi.org/10.1038/s41586-024-07385-1
State	Published - May 23 2024

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Tri-lab COVID-19 Consortium, Desautels, T. A., Arrildt, K. T., Zemla, A. T., Lau, E. Y., Zhu, F., Ricci, D., Cronin, S., Zost, S. J., Binshtein, E., Scheaffer, S. M., Dadonaite, B., Petersen, B. K., Engdahl, T. B., Chen, E., Handal, L. S., Hall, L., Goforth, J. W., Vashchenko, D., ... Faissol, D. M. (2024). Computationally restoring the potency of a clinical antibody against Omicron. Nature, 629(8013), 878-885. https://doi.org/10.1038/s41586-024-07385-1

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abstract = "By demonstrating a computational approach to restore the clinical efficacy of a COVID-19 antibody, the potential to rapidly update clinical antibodies is explored.",

author = "{Tri-lab COVID-19 Consortium} and Desautels, {Thomas A.} and Arrildt, {Kathryn T.} and Zemla, {Adam T.} and Lau, {Edmond Y.} and Fangqiang Zhu and Dante Ricci and Stephanie Cronin and Zost, {Seth J.} and Elad Binshtein and Scheaffer, {Suzanne M.} and Bernadeta Dadonaite and Petersen, {Brenden K.} and Engdahl, {Taylor B.} and Elaine Chen and Handal, {Laura S.} and Lynn Hall and Goforth, {John W.} and Denis Vashchenko and Sam Nguyen and Weilhammer, {Dina R.} and Lo, {Jacky Kai Yin} and Bonnee Rubinfeld and Saada, {Edwin A.} and Tracy Weisenberger and Lee, {Tek Hyung} and Bradley Whitener and Case, {James B.} and Alexander Ladd and Silva, {Mary S.} and Haluska, {Rebecca M.} and Grzesiak, {Emilia A.} and Earnhart, {Christopher G.} and Svetlana Hopkins and Bates, {Thomas W.} and Thackray, {Larissa B.} and Segelke, {Brent W.} and Lyon, {Emily Z.Alipio} and Anderson, {Penelope S.} and Aram Avila-Herrera and Bennett, {William F.} and Bourguet, {Feliza A.} and Chen, {Julian C.} and Coleman, {Matthew A.} and Collette, {Nicole M.} and Anastasiia Davis and Vannest, {Byron D.} and Fong, {Erika J.} and Sean Gilmore and Goncalves, {Andre R.} and Hall, {Sara B.} and Brooke Harmon and Wei He and Hoang-Phou, {Steven A.} and Mikel Landajuela and Laurence, {Ted A.} and Lee, {Tek Hyung} and {Da Silva}, {Felipe Leno} and Chao Liu and Mundhenk, {Terrel N.} and Mohagheghi, {Mariam V.} and McIlroy, {Peter R.} and Pham, {Le Thanh Mai} and Sanchez, {Joseph C.} and Anupama Sinha and Solomon, {Emilia A.} and Nicholas Watkins and Jiachen Yang and Congwang Ye and Boya Zhang and Lillo, {Antonietta Maria} and Shivshankar Sundaram and Bloom, {Jesse D.} and Diamond, {Michael S.} and Crowe, {James E.} and Carnahan, {Robert H.} and Faissol, {Daniel M.}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2024.",

year = "2024",

month = may,

day = "23",

doi = "10.1038/s41586-024-07385-1",

language = "English",

volume = "629",

pages = "878--885",

journal = "Nature",

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Tri-lab COVID-19 Consortium, Desautels, TA, Arrildt, KT, Zemla, AT, Lau, EY, Zhu, F, Ricci, D, Cronin, S, Zost, SJ, Binshtein, E, Scheaffer, SM, Dadonaite, B, Petersen, BK, Engdahl, TB, Chen, E, Handal, LS, Hall, L, Goforth, JW, Vashchenko, D, Nguyen, S, Weilhammer, DR, Lo, JKY, Rubinfeld, B, Saada, EA, Weisenberger, T, Lee, TH, Whitener, B, Case, JB, Ladd, A, Silva, MS, Haluska, RM, Grzesiak, EA, Earnhart, CG, Hopkins, S, Bates, TW, Thackray, LB, Segelke, BW, Lyon, EZA, Anderson, PS, Avila-Herrera, A, Bennett, WF, Bourguet, FA, Chen, JC, Coleman, MA, Collette, NM, Davis, A, Vannest, BD, Fong, EJ, Gilmore, S, Goncalves, AR, Hall, SB, Harmon, B, He, W, Hoang-Phou, SA, Landajuela, M, Laurence, TA, Lee, TH, Da Silva, FL, Liu, C, Mundhenk, TN, Mohagheghi, MV, McIlroy, PR, Pham, LTM, Sanchez, JC, Sinha, A, Solomon, EA, Watkins, N, Yang, J, Ye, C, Zhang, B, Lillo, AM, Sundaram, S, Bloom, JD, Diamond, MS, Crowe, JE, Carnahan, RH & Faissol, DM 2024, 'Computationally restoring the potency of a clinical antibody against Omicron', Nature, vol. 629, no. 8013, pp. 878-885. https://doi.org/10.1038/s41586-024-07385-1

TY - JOUR

T1 - Computationally restoring the potency of a clinical antibody against Omicron

AU - Tri-lab COVID-19 Consortium

AU - Desautels, Thomas A.

AU - Arrildt, Kathryn T.

AU - Zemla, Adam T.

AU - Lau, Edmond Y.

AU - Zhu, Fangqiang

AU - Ricci, Dante

AU - Cronin, Stephanie

AU - Zost, Seth J.

AU - Binshtein, Elad

AU - Scheaffer, Suzanne M.

AU - Dadonaite, Bernadeta

AU - Petersen, Brenden K.

AU - Engdahl, Taylor B.

AU - Chen, Elaine

AU - Handal, Laura S.

AU - Hall, Lynn

AU - Goforth, John W.

AU - Vashchenko, Denis

AU - Nguyen, Sam

AU - Weilhammer, Dina R.

AU - Lo, Jacky Kai Yin

AU - Rubinfeld, Bonnee

AU - Saada, Edwin A.

AU - Weisenberger, Tracy

AU - Lee, Tek Hyung

AU - Whitener, Bradley

AU - Case, James B.

AU - Ladd, Alexander

AU - Silva, Mary S.

AU - Haluska, Rebecca M.

AU - Grzesiak, Emilia A.

AU - Earnhart, Christopher G.

AU - Hopkins, Svetlana

AU - Bates, Thomas W.

AU - Thackray, Larissa B.

AU - Segelke, Brent W.

AU - Lyon, Emily Z.Alipio

AU - Anderson, Penelope S.

AU - Avila-Herrera, Aram

AU - Bennett, William F.

AU - Bourguet, Feliza A.

AU - Chen, Julian C.

AU - Coleman, Matthew A.

AU - Collette, Nicole M.

AU - Davis, Anastasiia

AU - Vannest, Byron D.

AU - Fong, Erika J.

AU - Gilmore, Sean

AU - Goncalves, Andre R.

AU - Hall, Sara B.

AU - Harmon, Brooke

AU - He, Wei

AU - Hoang-Phou, Steven A.

AU - Landajuela, Mikel

AU - Laurence, Ted A.

AU - Lee, Tek Hyung

AU - Da Silva, Felipe Leno

AU - Liu, Chao

AU - Mundhenk, Terrel N.

AU - Mohagheghi, Mariam V.

AU - McIlroy, Peter R.

AU - Pham, Le Thanh Mai

AU - Sanchez, Joseph C.

AU - Sinha, Anupama

AU - Solomon, Emilia A.

AU - Watkins, Nicholas

AU - Yang, Jiachen

AU - Ye, Congwang

AU - Zhang, Boya

AU - Lillo, Antonietta Maria

AU - Sundaram, Shivshankar

AU - Bloom, Jesse D.

AU - Diamond, Michael S.

AU - Crowe, James E.

AU - Carnahan, Robert H.

AU - Faissol, Daniel M.

PY - 2024/5/23

Y1 - 2024/5/23

N2 - By demonstrating a computational approach to restore the clinical efficacy of a COVID-19 antibody, the potential to rapidly update clinical antibodies is explored.

AB - By demonstrating a computational approach to restore the clinical efficacy of a COVID-19 antibody, the potential to rapidly update clinical antibodies is explored.

UR - http://www.scopus.com/inward/record.url?scp=85193839440&partnerID=8YFLogxK

U2 - 10.1038/s41586-024-07385-1

DO - 10.1038/s41586-024-07385-1

M3 - Article

C2 - 38720086

AN - SCOPUS:85193839440

SN - 0028-0836

VL - 629

SP - 878

EP - 885

JO - Nature

JF - Nature

IS - 8013

ER -

Computationally restoring the potency of a clinical antibody against Omicron

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