TY - GEN
T1 - Computational characterization and identification of core promoters of MicroRNA genes in C. elegans, H. sapiens and A. thaliana
AU - Zhou, Xuefeng
AU - Ruan, Jianhua
AU - Wang, Guandong
AU - Zhang, Weixiong
PY - 2007
Y1 - 2007
N2 - MicroRNAs are short, noncoding RNAs that play important roles in post-transcriptional regulation. Although many functions of microRNAs in plants and animals have been revealed in recent years, the transcriptional mechanism of microRNA genes is not well understood. To elucidate the transcriptional regulation of microRNA genes, we study and characterize, in a genome scale, the promoters of intergenic microRNA genes in Caenorhabditis elegans, Homo sapiens and Arabidopsis thaliana. Specifically, we show that the known microRNA genes in these species have the same type of promoters as the protein-coding genes. To further characterize the promoters of miRNA genes, we develop a miRNA core promoter prediction method, called common query voting (CoVote). We applied this new method to identify putative core promoters of most known microRNA genes in the three model species of choice.
AB - MicroRNAs are short, noncoding RNAs that play important roles in post-transcriptional regulation. Although many functions of microRNAs in plants and animals have been revealed in recent years, the transcriptional mechanism of microRNA genes is not well understood. To elucidate the transcriptional regulation of microRNA genes, we study and characterize, in a genome scale, the promoters of intergenic microRNA genes in Caenorhabditis elegans, Homo sapiens and Arabidopsis thaliana. Specifically, we show that the known microRNA genes in these species have the same type of promoters as the protein-coding genes. To further characterize the promoters of miRNA genes, we develop a miRNA core promoter prediction method, called common query voting (CoVote). We applied this new method to identify putative core promoters of most known microRNA genes in the three model species of choice.
UR - http://www.scopus.com/inward/record.url?scp=34547481983&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:34547481983
SN - 3540482938
SN - 9783540482932
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 235
EP - 248
BT - Systems Biology and Regulatory Genomics - Joint Annual RECOMB 2005 Satellite Workshops on Systems Biology and on Regulatory Genomics, Revised Selected Papers
T2 - Joint Annual RECOMB 2005 Satellite Workshops on Systems Biology and on Regulatory Genomics
Y2 - 2 December 2005 through 4 December 2005
ER -