Computation of molecular weight averages for DNA molecules containing both preformed and randomly induced single‐strand breaks

We derive equations for calculating the number‐, weight‐, and z‐average lengths between single‐strand breaks in DNA molecules. Provision is made for the existence of preformed breaks under genetic control: these are assumed to be fixed in number in each molecule, but may be variable in position. Breaks due to random degradation may be superimposed on the pre‐existing breaks. An example is given for illustrative purposes.