Compressive mechanical properties of the human anulus fibrosus and their relationship to biochemical composition

Barbara A. Best, Farshid Guilak, Lori A. Setton, Wenbo Zhu, Fatemeh Saed-Nejad, Anthony Ratcliffe, Mark Weidenbaum, M. Van

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Abstract

Tq enfianca understand mg of the biomechantcal role of the IntOrveriObral disc, the com press ivu properties and biochemical com portion ot nondegenerete samples of anulus fibrosus were ceterm ncc as a function Df f arils I pO$itiOhr region, flrtd f&Vel, BefituCe of the large swelling propensity of this tissue, a method was developed Id tost oxcisod spcc.mens wIiiIh maintaining ths-ir in situ gaometry and Hydration- Using an analysis based on linear biphasic theory, the eomprcssivo modulus, hydraulic permeability, and isometric spelling pressure of the anulus fibrosus were determined and correlated with the tissue composition. The findings indicate [hat the anuiLis fibrosus is in homogeneous, with regional and radief variations in both material properties anc biochemical composition. The results of I his study sug- gesl the! bo!h structural and compositional factors may determine the mechanical behavior.

Original languageEnglish
Pages (from-to)212-221
Number of pages10
JournalSpine
Volume19
Issue number2
StatePublished - Jan 1994
Externally publishedYes

Keywords

  • Anulus flbfiKtiSr ijitervertebrfli disc
  • Collagen
  • Compresslvts properties
  • Hi phasic
  • Proteogtycan
  • Swelling pressure

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    Best, B. A., Guilak, F., Setton, L. A., Zhu, W., Saed-Nejad, F., Ratcliffe, A., Weidenbaum, M., & Van, M. (1994). Compressive mechanical properties of the human anulus fibrosus and their relationship to biochemical composition. Spine, 19(2), 212-221.