TY - JOUR
T1 - Compressive mechanical properties of the human anulus fibrosus and their relationship to biochemical composition
AU - Best, Barbara A.
AU - Guilak, Farshid
AU - Setton, Lori A.
AU - Zhu, Wenbo
AU - Saed-Nejad, Fatemeh
AU - Ratcliffe, Anthony
AU - Weidenbaum, Mark
AU - Van, M.
PY - 1994/1
Y1 - 1994/1
N2 - Tq enfianca understand mg of the biomechantcal role of the IntOrveriObral disc, the com press ivu properties and biochemical com portion ot nondegenerete samples of anulus fibrosus were ceterm ncc as a function Df f arils I pO$itiOhr region, flrtd f&Vel, BefituCe of the large swelling propensity of this tissue, a method was developed Id tost oxcisod spcc.mens wIiiIh maintaining ths-ir in situ gaometry and Hydration- Using an analysis based on linear biphasic theory, the eomprcssivo modulus, hydraulic permeability, and isometric spelling pressure of the anulus fibrosus were determined and correlated with the tissue composition. The findings indicate [hat the anuiLis fibrosus is in homogeneous, with regional and radief variations in both material properties anc biochemical composition. The results of I his study sug- gesl the! bo!h structural and compositional factors may determine the mechanical behavior.
AB - Tq enfianca understand mg of the biomechantcal role of the IntOrveriObral disc, the com press ivu properties and biochemical com portion ot nondegenerete samples of anulus fibrosus were ceterm ncc as a function Df f arils I pO$itiOhr region, flrtd f&Vel, BefituCe of the large swelling propensity of this tissue, a method was developed Id tost oxcisod spcc.mens wIiiIh maintaining ths-ir in situ gaometry and Hydration- Using an analysis based on linear biphasic theory, the eomprcssivo modulus, hydraulic permeability, and isometric spelling pressure of the anulus fibrosus were determined and correlated with the tissue composition. The findings indicate [hat the anuiLis fibrosus is in homogeneous, with regional and radief variations in both material properties anc biochemical composition. The results of I his study sug- gesl the! bo!h structural and compositional factors may determine the mechanical behavior.
KW - Anulus flbfiKtiSr ijitervertebrfli disc
KW - Collagen
KW - Compresslvts properties
KW - Hi phasic
KW - Proteogtycan
KW - Swelling pressure
UR - http://www.scopus.com/inward/record.url?scp=0028117251&partnerID=8YFLogxK
U2 - 10.1097/00007632-199401001-00017
DO - 10.1097/00007632-199401001-00017
M3 - Article
C2 - 8153833
AN - SCOPUS:0028117251
SN - 0362-2436
VL - 19
SP - 212
EP - 221
JO - Spine
JF - Spine
IS - 2
ER -