Comprehensive workflow and its validation for simulating diffuse speckle statistics for optical blood flow measurements

Lisa Kobayashi Frisk; Manish Verma; Faruk Bešlija; Chen Hao P. Lin; Nishighanda Patil; Sumana Chetia; Jason W. Trobaugh; Joseph P. Culver; Turgut Durduran

doi:10.1364/BOE.502421

Comprehensive workflow and its validation for simulating diffuse speckle statistics for optical blood flow measurements

Lisa Kobayashi Frisk, Manish Verma, Faruk Bešlija, Chen Hao P. Lin, Nishighanda Patil, Sumana Chetia, Jason W. Trobaugh, Joseph P. Culver, Turgut Durduran

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Diffuse optical methods including speckle contrast optical spectroscopy and tomography (SCOS and SCOT), use speckle contrast (κ) to measure deep blood flow. In order to design practical systems, parameters such as signal-to-noise ratio (SNR) and the effects of limited sampling of statistical quantities, should be considered. To that end, we have developed a method for simulating speckle contrast signals including effects of detector noise. The method was validated experimentally, and the simulations were used to study the effects of physical and experimental parameters on the accuracy and precision of κ. These results revealed that systematic detector effects resulted in decreased accuracy and precision of κ in the regime of low detected signals. The method can provide guidelines for the design and usage of SCOS and/or SCOT instruments.

Original language	English
Pages (from-to)	875-899
Number of pages	25
Journal	Biomedical Optics Express
Volume	15
Issue number	2
DOIs	https://doi.org/10.1364/BOE.502421
State	Published - Feb 10 2024

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title = "Comprehensive workflow and its validation for simulating diffuse speckle statistics for optical blood flow measurements",

abstract = "Diffuse optical methods including speckle contrast optical spectroscopy and tomography (SCOS and SCOT), use speckle contrast (κ) to measure deep blood flow. In order to design practical systems, parameters such as signal-to-noise ratio (SNR) and the effects of limited sampling of statistical quantities, should be considered. To that end, we have developed a method for simulating speckle contrast signals including effects of detector noise. The method was validated experimentally, and the simulations were used to study the effects of physical and experimental parameters on the accuracy and precision of κ. These results revealed that systematic detector effects resulted in decreased accuracy and precision of κ in the regime of low detected signals. The method can provide guidelines for the design and usage of SCOS and/or SCOT instruments.",

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T1 - Comprehensive workflow and its validation for simulating diffuse speckle statistics for optical blood flow measurements

AU - Frisk, Lisa Kobayashi

AU - Verma, Manish

AU - Bešlija, Faruk

AU - Lin, Chen Hao P.

AU - Patil, Nishighanda

AU - Chetia, Sumana

AU - Trobaugh, Jason W.

AU - Culver, Joseph P.

AU - Durduran, Turgut

PY - 2024/2/10

Y1 - 2024/2/10

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AB - Diffuse optical methods including speckle contrast optical spectroscopy and tomography (SCOS and SCOT), use speckle contrast (κ) to measure deep blood flow. In order to design practical systems, parameters such as signal-to-noise ratio (SNR) and the effects of limited sampling of statistical quantities, should be considered. To that end, we have developed a method for simulating speckle contrast signals including effects of detector noise. The method was validated experimentally, and the simulations were used to study the effects of physical and experimental parameters on the accuracy and precision of κ. These results revealed that systematic detector effects resulted in decreased accuracy and precision of κ in the regime of low detected signals. The method can provide guidelines for the design and usage of SCOS and/or SCOT instruments.

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Comprehensive workflow and its validation for simulating diffuse speckle statistics for optical blood flow measurements

Abstract

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