Comprehensive workflow and its validation for simulating diffuse speckle statistics for optical blood flow measurements

Lisa Kobayashi Frisk, Manish Verma, Faruk Bešlija, Chen Hao P. Lin, Nishighanda Patil, Sumana Chetia, Jason W. Trobaugh, Joseph P. Culver, Turgut Durduran

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Diffuse optical methods including speckle contrast optical spectroscopy and tomography (SCOS and SCOT), use speckle contrast (κ) to measure deep blood flow. In order to design practical systems, parameters such as signal-to-noise ratio (SNR) and the effects of limited sampling of statistical quantities, should be considered. To that end, we have developed a method for simulating speckle contrast signals including effects of detector noise. The method was validated experimentally, and the simulations were used to study the effects of physical and experimental parameters on the accuracy and precision of κ. These results revealed that systematic detector effects resulted in decreased accuracy and precision of κ in the regime of low detected signals. The method can provide guidelines for the design and usage of SCOS and/or SCOT instruments.

Original languageEnglish
Pages (from-to)875-899
Number of pages25
JournalBiomedical Optics Express
Volume15
Issue number2
DOIs
StatePublished - Feb 10 2024

Fingerprint

Dive into the research topics of 'Comprehensive workflow and its validation for simulating diffuse speckle statistics for optical blood flow measurements'. Together they form a unique fingerprint.

Cite this