Comprehensive review of post–organ transplant hematologic cancers

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28 Scopus citations

Abstract

A higher risk for a variety of cancers is among the major complications of posttransplantation immunosuppression. In this part of a continuing series on cancers posttransplantation, this review focuses on the hematologic cancers after solid organ transplantation. Posttransplantation lymphoproliferative disorders (PTLDs), which comprise the great majority of hematologic cancers, represent a spectrum of conditions that include, but are not limited to, the Hodgkin and non-Hodgkin lymphomas. The oncogenic Epstein-Barr virus is a key pathogenic driver in many PTLD cases, through known and unknown mechanisms. The other hematologic cancers include leukemias and plasma cell neoplasms (multiple myeloma and plasmacytoma). Clinical features vary across malignancies and location. Preventive screening strategies have been attempted mainly for PTLDs. Treatments include the chemotherapy regimens for the specific cancers, but also include reduction of immunosuppression, rituximab, and other therapies.

Original languageEnglish
Pages (from-to)537-549
Number of pages13
JournalAmerican Journal of Transplantation
Volume18
Issue number3
DOIs
StatePublished - Mar 2018

Keywords

  • cancer/malignancy/neoplasia
  • cancer/malignancy/neoplasia: hematogenous/leukemia/lymphoma
  • cancer/malignancy/neoplasia: registry/incidence
  • clinical research/practice
  • hematology/oncology
  • organ transplantation in general
  • translational research/science

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