@article{04e7eb7cabd64dac9ed6cd5f64f71dba,
title = "Complications, Visual Acuity, and Refractive Error 3 Years after Secondary Intraocular Lens Implantation for Pediatric Aphakia",
abstract = "Purpose: To report the cumulative incidence of complications and to describe refractive error and visual acuity (VA) outcomes in children undergoing secondary intraocular lens (IOL) implantation after previous surgery for nontraumatic cataract. Design: Pediatric cataract registry. Participants: Eighty children (108 eyes: 60 bilateral, 48 unilateral) undergoing lensectomy at younger than 13 years of age. Methods: Annual data collection from medical record review through 5 years after lensectomy. Main Outcome Measures: Cumulative incidence of newly emergent complications after secondary IOL implantation; refractive error and VA by 5 years after lensectomy. Results: Median follow-up after secondary IOL implantation was 2.7 years (interquartile range [IQR], 0.8–3.3 years; range, 0.6–5.0 years) for bilateral and 2.1 years (range, 0.5–6.4 years) for unilateral cases. A common complication after secondary IOL implantation was a glaucoma-related adverse event (GRAE; glaucoma or glaucoma suspect); the cumulative incidence was 17% (95% confidence interval [CI], 3%–29%) in bilateral cases and 12% (95% CI, 0%–23%) in unilateral cases. The cumulative incidence of surgery for visual axis opacification was 2% (95% CI, 0%–7%) for bilateral cases and 4% (95% CI, 0%–10%) for unilateral cases. The median prediction error within 90 days of implantation was 0.88 diopter (D; IQR, –0.50 to +3.00 D) less hyperopic than intended among 21 eyes for bilateral cases and 1.50 D (IQR, –0.25 to +2.38 D) less among 19 unilateral cases. The median spherical equivalent refractive error at 5 years (at a median of 5.1 years of age) in eyes receiving a secondary IOL was +0.50 D (IQR, –2.38 to +2.94 D) for 48 bilateral cases and +0.06 D (IQR, –2.25 to +0.75 D) for 22 unilateral cases. Median monocular VA at 5 years was 20/63 (IQR, 20/50–20/100) for bilateral cases (n = 42) and 20/400 (IQR, 20/160–20/800) for unilateral cases (n = 33). Conclusions: Eyes with secondary IOL implantation have a risk of developing new GRAEs. Five years after lensectomy (approximately 2.5 years after secondary IOL implantation), the average refractive error was less hyperopic than desired given the anticipated further myopic shift before refraction stabilizes. Financial Disclosure(s): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.",
keywords = "Aphakia, Intraocular lenses, Pediatric cataract",
author = "{Pediatric Eye Disease Investigator Group} and Serena Wang and Repka, {Michael X.} and Sutherland, {Desirae R.} and Hatt, {Sarah R.} and Traboulsi, {Elias I.} and Lambert, {Scott R.} and Melia, {B. Michele} and Kraker, {Raymond T.} and Holmes, {Jonathan M.} and Cotter, {Susan A.} and Freedman, {Sharon F.} and Wallace, {David K.} and Enyedi, {Laura B.} and Sasapin Prakalapakorn and Jones, {Sarah K.} and Denise Hug and Stahl, {Erin D.} and Dent, {Rebecca J.} and Lingkun Kong and Gallerson, {Bryan K.} and Hutchinson, {Amy K.} and Phoebe Lenhart and Judy Brower and Morrison, {David G.} and Ruark, {Scott T.} and Rebecca Mets-Halgrimson and Hawke Yoon and Hantamalala Ralay-Ranaivo and Aaliyah Hamidullah and Raymond Areaux and Anderson, {Jill S.} and Holleschau, {Ann M.} and Rosanne Superstein and Caroline Belanger and Nicole Fallaha and Patrick Hamel and Maryse Thibeault and Tamkins, {Susanna M.} and Ta Chang and Park, {Hee Jung S.} and Trumler, {Anya A.} and Xiaonong Liu and Astle, {William F.} and Sanders, {Emi N.} and Elias Traboulsi and Fatema Ghasia and McOwen, {Diana C.} and Gray, {Michael E.} and Yang, {Michael B.} and Bowman, {Corey S.} and Jennifer Galvin and Margaret Therriault and Heather Smith and Whitaker, {Michele E.} and Faruk Orge and Grigorian, {Adriana P.} and Baird, {Alicia M.} and Strominger, {Mitchell B.} and Vicki Chen and Shelley Klein and Kemmer, {Jacquelyn D.} and Neiman, {Alexandra E.} and Mendoza, {Myra N.} and Frohwein, {Jill J.} and Don Bremer and Cybil Cassady and Richard Golden and Catherine Jordan and David Rogers and Oravec, {Sara A.} and Yanovitch, {Tammy L.} and Keven Lunsford and Christina Nye and Caroline Shea and Stillman, {Sue Ann M.} and LaRoche, {G. Robert} and {Van Iderstine}, {Stephen C.} and Elisa Robertson and Cruz, {Oscar A.} and Rafif Ghadban and Dawn Govreau and Larson, {Scott A.} and Susannah Longmuir and Xiaoyan Shan and Clarke, {Michael P.} and Kate Taylor and Christine Powell and Hammond, {Benjamin P.} and Gearinger, {Matthew D.} and Andrea Czubinski and Hendricks, {Dorothy H.} and Jing Jin and Salvin, {Jonathan H.} and Alicia Fisher and Lee, {Katherine A.} and Daniel Brooks and Schweinler, {Bonita R.} and Sala, {Nicholas A.} and Sala, {Allyson M.} and Summers, {Allison I.} and Karr, {Daniel J.} and Wilson, {Lorri B.} and Rauch, {Paula K.} and Mary O'Hara and Nandini Gandhi and Tania Hashmi and Jeffrey Colburn and Eileen Dittman and Whitfill, {Charles R.} and Wheeler, {Amy M.} and McCourt, {Emily A.} and Jasleen Singh and Nanastasia Welnick and Azar, {Nathalie F.} and Joseph Baker and Droste, {Patrick J.} and Peters, {Robert J.} and Jan Hilbrands and Pineles, {Stacy L.} and Bernardo, {Marianne J.} and Edward Peterson and Peterson, {Charla H.} and Kartik Kumar and Ephrem Melese and Robert Lingua and Jeff Grijalva and Crouch, {Earl R.} and Gaylord Ventura and William Anninger and Benson, {Shawn L.} and Karp, {Karen A.} and Smith, {Jordana M.} and Jill Brickman-Kelleher and Ticho, {Benjamin H.} and Khammar, {Alexander J.} and Clausius, {Deborah A.} and Suquin Guo and Donny Suh and Carolyn Chamberlain and Susan Schloff and Madigan, {William P.} and Donna Burkman and Christiansen, {Stephen P.} and Ramsey, {Jean E.} and McConnell, {Kate H.} and Ilana Friedman and Jose Rosado and Sauberan, {Donald P.} and Hemberger, {Jody C.} and Davis, {Patricia L.} and Indre Rudaitis and Lowery, {Robert S.} and Shawn Cupit and Bothun, {Erick D.} and Mohney, {Brian G.} and Wernimont, {Suzanne M.} and Neilsen, {Rebecca A.} and Herlihy, {Erin P.} and Francine Baran and Amy Gladstone and Justin Smith and Mei Mellott and Troy Kieser and Erzurum, {S. Ayse} and Beth Colon and Birva Shah and Micaela Quebbemann and Beck, {Roy W.} and Austin, {Darrell S.} and Boyle, {Nicole M.} and Conner, {Courtney L.} and Chandler, {Danielle L.} and Quayleen Donahue and Fimbel, {Brooke P.} and Robinson, {Julianne L.} and Amra Hercinovic and Hoepner, {James E.} and Kaplon, {Joseph D.} and Henderson, {Robert J.} and Gillaine Ortiz and Woodard, {Victoria C.} and Stutz, {Kathleen M.} and Rui Wu and Everett, {Donald F.} and Marie Diener-West and Baker, {John D.} and Barry Davis and Phelps, {Dale L.} and Poff, {Stephen W.} and Saunders, {Richard A.} and Lawrence Tychsen and Bradfield, {Yasmin S.} and Foster, {Nicole C.} and Plager, {David A.} and Salchow, {Daniel J.} and Birch, {Eileen E.} and Manny, {Ruth E.} and Silver, {Jayne L.} and Weise, {Katherine K.} and Verderber, {Lisa C.}",
note = "Publisher Copyright: {\textcopyright} 2024 American Academy of Ophthalmology",
year = "2024",
month = oct,
doi = "10.1016/j.ophtha.2024.05.011",
language = "English",
volume = "131",
pages = "1196--1206",
journal = "Ophthalmology",
issn = "0161-6420",
number = "10",
}