Compliance with topical timolol treatment

M. A. Kass, M. Gordon, R. E. Morley, D. W. Meltzer, J. J. Goldberg

Research output: Contribution to journalArticlepeer-review

192 Scopus citations


To determine if compliance with timolol treatment was better than compliance with pilocarpine treatment (as reported previously), we measured compliance with timolol treatment in a sample of 110 patients using an unobtrusive eyedrop medication monitor, which recorded electronically the date and time of each drug administration over a four- to six-week period. The patients administered a mean ± S.D. of 82.7% ± 19.0% of the prescribed timolol doses (range, 20% to 100%). Forty-five patients were treated concurrently with timolol and pilocarpine. These patients administered a mean ± S.D. of 84.3% ± 14.0% of the prescribed pilocarpine doses (P=.012, and van der Waerden test). Our results suggest that while compliance is influenced by the drug regimen, defaulting is not eliminated by prescribing a more convenient medication with fewer side effects.

Original languageEnglish
Pages (from-to)188-193
Number of pages6
JournalAmerican journal of ophthalmology
Issue number2
StatePublished - 1987


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