Complex segregation analysis for a three‐allele locus: Experience from an analysis of acid phosphatase activity

L. Iselius, D. A.P. Evans, L. C. Eze, M. C.K. Tweedie, M. F. Bullen, P. J.J. Wren, D. C. Rao

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

A complex segregation analysis of acid phosphatase activity in 50 British families showed that the essential features of the acid phosphatase polymorphism, i.e., a major gene with three alleles, is retrieved by using the biallelic mixed model. The estimates of gene frequency and displacement obtained from segregation analysis were in agreement with those obtained from electrophoretic studies. In addition, there was evidence for a multifactorial component.

Original languageEnglish
Pages (from-to)619-624
Number of pages6
JournalGenetic Epidemiology
Volume6
Issue number5
DOIs
StatePublished - 1989
Externally publishedYes

Keywords

  • enzyme activity
  • genetics
  • major locus

Fingerprint Dive into the research topics of 'Complex segregation analysis for a three‐allele locus: Experience from an analysis of acid phosphatase activity'. Together they form a unique fingerprint.

  • Cite this