Complex segregation analysis for a three‐allele locus: Experience from an analysis of acid phosphatase activity

L. Iselius; D. A.P. Evans; L. C. Eze; M. C.K. Tweedie; M. F. Bullen; P. J.J. Wren; D. C. Rao

doi:10.1002/gepi.1370060506

Complex segregation analysis for a three‐allele locus: Experience from an analysis of acid phosphatase activity

L. Iselius, D. A.P. Evans, L. C. Eze, M. C.K. Tweedie, M. F. Bullen, P. J.J. Wren, D. C. Rao

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Abstract

A complex segregation analysis of acid phosphatase activity in 50 British families showed that the essential features of the acid phosphatase polymorphism, i.e., a major gene with three alleles, is retrieved by using the biallelic mixed model. The estimates of gene frequency and displacement obtained from segregation analysis were in agreement with those obtained from electrophoretic studies. In addition, there was evidence for a multifactorial component.

Original language	English
Pages (from-to)	619-624
Number of pages	6
Journal	Genetic Epidemiology
Volume	6
Issue number	5
DOIs	https://doi.org/10.1002/gepi.1370060506
State	Published - 1989

Keywords

enzyme activity
genetics
major locus

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title = "Complex segregation analysis for a three‐allele locus: Experience from an analysis of acid phosphatase activity",

abstract = "A complex segregation analysis of acid phosphatase activity in 50 British families showed that the essential features of the acid phosphatase polymorphism, i.e., a major gene with three alleles, is retrieved by using the biallelic mixed model. The estimates of gene frequency and displacement obtained from segregation analysis were in agreement with those obtained from electrophoretic studies. In addition, there was evidence for a multifactorial component.",

keywords = "enzyme activity, genetics, major locus",

author = "L. Iselius and Evans, {D. A.P.} and Eze, {L. C.} and Tweedie, {M. C.K.} and Bullen, {M. F.} and Wren, {P. J.J.} and Rao, {D. C.}",

year = "1989",

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language = "English",

volume = "6",

pages = "619--624",

journal = "Genetic Epidemiology",

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T1 - Complex segregation analysis for a three‐allele locus

T2 - Experience from an analysis of acid phosphatase activity

AU - Iselius, L.

AU - Evans, D. A.P.

AU - Eze, L. C.

AU - Tweedie, M. C.K.

AU - Bullen, M. F.

AU - Wren, P. J.J.

AU - Rao, D. C.

PY - 1989

Y1 - 1989

N2 - A complex segregation analysis of acid phosphatase activity in 50 British families showed that the essential features of the acid phosphatase polymorphism, i.e., a major gene with three alleles, is retrieved by using the biallelic mixed model. The estimates of gene frequency and displacement obtained from segregation analysis were in agreement with those obtained from electrophoretic studies. In addition, there was evidence for a multifactorial component.

AB - A complex segregation analysis of acid phosphatase activity in 50 British families showed that the essential features of the acid phosphatase polymorphism, i.e., a major gene with three alleles, is retrieved by using the biallelic mixed model. The estimates of gene frequency and displacement obtained from segregation analysis were in agreement with those obtained from electrophoretic studies. In addition, there was evidence for a multifactorial component.

KW - enzyme activity

KW - genetics

KW - major locus

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U2 - 10.1002/gepi.1370060506

DO - 10.1002/gepi.1370060506

M3 - Article

C2 - 2591731

AN - SCOPUS:0024451711

SN - 0741-0395

VL - 6

SP - 619

EP - 624

JO - Genetic Epidemiology

JF - Genetic Epidemiology

IS - 5

ER -

Complex segregation analysis for a three‐allele locus: Experience from an analysis of acid phosphatase activity

Abstract

Keywords

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