Complex responses activated by ibotenate in postnatal rat hippocampal neurons

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Abstract

The actions of the excitatory amino acid ibotenate were investigated in postnatal rat hippocampal neurons. In neurons voltage clamped at negative membrane potentials using low-chloride internal solutions, ibotenate responses consist of an inward cationic current and two outward currents. The inward current is inhibited by 2-amino-5-phosphonovalerate (APV), a selective N-methyl-d-aspartate (NMDA) antagonist. The two outward currents consist of a picrotoxin and bicuculline-sensitive chloride current and a slowly developing calcium activated potassium current. The bicuculline sensitive current appears to be the product of contamination of ibotenate samples with the γ-aminobutyric acid (GABA) agonist muscimol and not the result of a direct action of ibotenate.

Original languageEnglish
Pages (from-to)193-197
Number of pages5
JournalBrain Research
Volume494
Issue number1
DOIs
StatePublished - Aug 7 1989

Keywords

  • Chloride current
  • Ibotenate
  • Muscimol
  • N-Methyl-d-aspartate
  • Voltage clamp

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