TY - JOUR
T1 - Complex physiology and clinical implications of time-restricted eating
AU - Petersen, Max C.
AU - Gallop, Molly R.
AU - Ramos, Stephany Flores
AU - Zarrinpar, Amir
AU - Broussard, Josiane L.
AU - Chondronikola, Maria
AU - Chaix, Amandine
AU - Klein, Samuel
N1 - Publisher Copyright:
© 2022 the American Physiological Society.
PY - 2022/10
Y1 - 2022/10
N2 - Time-restricted eating (TRE) is a dietary intervention that limits food consumption to a specific time window each day. The effect of TRE on body weight and physiological functions has been extensively studied in rodent models, which have shown considerable therapeutic effects of TRE and important interactions among time of eating, circadian biology, and metabolic homeostasis. In contrast, it is difficult to make firm conclusions regarding the effect of TRE in people because of the heterogeneity in results, TRE regimens, and study populations. In this review, we 1) provide a background of the history of meal consumption in people and the normal physiology of eating and fasting; 2) discuss the interaction between circadian molecular metabolism and TRE; 3) integrate the results of preclinical and clinical studies that evaluated the effects of TRE on body weight and physiological functions; 4) summarize other time-related dietary interventions that have been studied in people; and 4) identify current gaps in knowledge and provide a framework for future research directions.
AB - Time-restricted eating (TRE) is a dietary intervention that limits food consumption to a specific time window each day. The effect of TRE on body weight and physiological functions has been extensively studied in rodent models, which have shown considerable therapeutic effects of TRE and important interactions among time of eating, circadian biology, and metabolic homeostasis. In contrast, it is difficult to make firm conclusions regarding the effect of TRE in people because of the heterogeneity in results, TRE regimens, and study populations. In this review, we 1) provide a background of the history of meal consumption in people and the normal physiology of eating and fasting; 2) discuss the interaction between circadian molecular metabolism and TRE; 3) integrate the results of preclinical and clinical studies that evaluated the effects of TRE on body weight and physiological functions; 4) summarize other time-related dietary interventions that have been studied in people; and 4) identify current gaps in knowledge and provide a framework for future research directions.
KW - Chrononutrition
KW - Intermittent fasting
KW - Nutrition
KW - Obesity
KW - Time-restricted eating
UR - http://www.scopus.com/inward/record.url?scp=85137126408&partnerID=8YFLogxK
U2 - 10.1152/physrev.00006.2022
DO - 10.1152/physrev.00006.2022
M3 - Review article
C2 - 35834774
AN - SCOPUS:85137126408
SN - 0031-9333
VL - 102
SP - 1991
EP - 2034
JO - Physiological reviews
JF - Physiological reviews
IS - 4
ER -