TY - JOUR
T1 - Complete posterior vitreous detachment reduces the need for treatment of diabetic macular edema
AU - Anderson, William
AU - Piggott, Kisha
AU - Bao, Yicheng K.
AU - Pham, Hang
AU - Kavali, Sweta
AU - Rajagopal, Rithwick
N1 - Funding Information:
Originally submitted September 16, 2018. Revision received January 27, 2019. Accepted for publication March 22, 2019. Supported by NIH/NEI grant EY025269 (RR), NIH/NIDDK grant T32DK007120 (YKB), a Career Development Award from Research to Prevent Blindness (RR), the Horncrest Foundation Support (RR), UMKC School of Medicine Sarah Morrison Research Award (YKB), NIH/NEI grant P30 EY002687 to Washington University School of Medicine Department of Ophthalmology and Visual Sciences, and an Unrestricted Award to Washington University School of Medicine Department of Ophthalmology and Visual Sciences from Research to Prevent Blindness. The authors report no relevant financial disclosures. The authors would like to thank Dr. David Beebe for his insightful discussions related to this topic, which sparked the questions inspiring this study. Address correspondence to Rithwick Rajagopal, MD, PhD, Washington University School of Medicine, Campus Box 8096, 660 South Euclid Ave., St. Louis, MO 63110; email: rajagopalr@wustl.edu. doi: 10.3928/23258160-20191031-13
Publisher Copyright:
© 2019 Slack Incorporated. All rights reserved.
PY - 2019
Y1 - 2019
N2 - BACKGROUND AND OBJECTIVE: To evaluate the vitreomacular interface and its relation to treatment burden for diabetic macular edema (DME) in patients without overt vitreomacular traction (VMT). PATIENTS AND METHODS: A retrospective cohort study of 494 eyes from 274 patients who had macular spectral-domain optical coherence tomography (SD-OCT) and did not have proliferative diabetic retinopathy, DME, or VMT at the initial visit. Posterior vitreous detachment (PVD) was categorized at the initial visit into five stages (0-4) using SD-OCT parameters alone. RESULTS: Two of 34 eyes (6.9%) presenting with a complete PVD required DME treatment during follow-up, whereas 144 of 460 eyes (31.3%) without a complete PVD at baseline required treatment (P = .001, Chi-squared). After adjusting for age, ethnicity, gender, and HbA1c, complete PVD at baseline was associated with a significant reduction in risk of DME therapy (hazard ratio: 0.18; 95% confidence interval, 0.05-0.73; P = .02). CONCLUSION: Complete PVD is independently associated with a reduced need for DME treatment.
AB - BACKGROUND AND OBJECTIVE: To evaluate the vitreomacular interface and its relation to treatment burden for diabetic macular edema (DME) in patients without overt vitreomacular traction (VMT). PATIENTS AND METHODS: A retrospective cohort study of 494 eyes from 274 patients who had macular spectral-domain optical coherence tomography (SD-OCT) and did not have proliferative diabetic retinopathy, DME, or VMT at the initial visit. Posterior vitreous detachment (PVD) was categorized at the initial visit into five stages (0-4) using SD-OCT parameters alone. RESULTS: Two of 34 eyes (6.9%) presenting with a complete PVD required DME treatment during follow-up, whereas 144 of 460 eyes (31.3%) without a complete PVD at baseline required treatment (P = .001, Chi-squared). After adjusting for age, ethnicity, gender, and HbA1c, complete PVD at baseline was associated with a significant reduction in risk of DME therapy (hazard ratio: 0.18; 95% confidence interval, 0.05-0.73; P = .02). CONCLUSION: Complete PVD is independently associated with a reduced need for DME treatment.
UR - http://www.scopus.com/inward/record.url?scp=85075486510&partnerID=8YFLogxK
U2 - 10.3928/23258160-20191031-13
DO - 10.3928/23258160-20191031-13
M3 - Article
C2 - 31755977
AN - SCOPUS:85075486510
SN - 2325-8160
VL - 50
SP - E266-E273
JO - Ophthalmic Surgery Lasers and Imaging Retina
JF - Ophthalmic Surgery Lasers and Imaging Retina
IS - 11
ER -