Complete nucleotide sequence of the AIDS virus, HTLV-III

Lee Ratner; William Haseltine; Roberto Patarca; Kenneth J. Livak; Bruno Starcich; Steven F. Josephs; Ellen R. Doran; J. Antoni Rafalski; Erik A. Whitehorn; Kirk Baumeister; Lucinda Ivanoff; Stephen R. Petteway; Mark L. Pearson; James A. Lautenberger; Takis S. Papas; John Ghrayeb; Nancy T. Chang; Robert C. Gallo; Flossie Wong-Staal

doi:10.1038/313277a0

Complete nucleotide sequence of the AIDS virus, HTLV-III

Lee Ratner, William Haseltine, Roberto Patarca, Kenneth J. Livak, Bruno Starcich, Steven F. Josephs, Ellen R. Doran, J. Antoni Rafalski, Erik A. Whitehorn, Kirk Baumeister, Lucinda Ivanoff, Stephen R. Petteway, Mark L. Pearson, James A. Lautenberger, Takis S. Papas, John Ghrayeb, Nancy T. Chang, Robert C. Gallo, Flossie Wong-Staal

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Abstract

The complete nucleotide sequence of two human T-cell leukaemia type III (HTLV-III) proviral DNAs each have four long open reading frames, the first two corresponding to the gag and pol genes. The fourth open reading frame encodes two functional polypeptides, a large precursor of the major envelope glycoprotein and a smaller protein derived from the 3′-terminus long open reading frame analogous to the long open reading frame (lor) product of HTLV-I and -II.

Original language	English
Pages (from-to)	277-284
Number of pages	8
Journal	Nature
Volume	313
Issue number	6000
DOIs	https://doi.org/10.1038/313277a0
State	Published - 1985

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Ratner, L., Haseltine, W., Patarca, R., Livak, K. J., Starcich, B., Josephs, S. F., Doran, E. R., Rafalski, J. A., Whitehorn, E. A., Baumeister, K., Ivanoff, L., Petteway, S. R., Pearson, M. L., Lautenberger, J. A., Papas, T. S., Ghrayeb, J., Chang, N. T., Gallo, R. C., & Wong-Staal, F. (1985). Complete nucleotide sequence of the AIDS virus, HTLV-III. Nature, 313(6000), 277-284. https://doi.org/10.1038/313277a0

@article{32dec5c9a25a48a6906db9100822e9e8,

title = "Complete nucleotide sequence of the AIDS virus, HTLV-III",

abstract = "The complete nucleotide sequence of two human T-cell leukaemia type III (HTLV-III) proviral DNAs each have four long open reading frames, the first two corresponding to the gag and pol genes. The fourth open reading frame encodes two functional polypeptides, a large precursor of the major envelope glycoprotein and a smaller protein derived from the 3′-terminus long open reading frame analogous to the long open reading frame (lor) product of HTLV-I and -II.",

author = "Lee Ratner and William Haseltine and Roberto Patarca and Livak, {Kenneth J.} and Bruno Starcich and Josephs, {Steven F.} and Doran, {Ellen R.} and Rafalski, {J. Antoni} and Whitehorn, {Erik A.} and Kirk Baumeister and Lucinda Ivanoff and Petteway, {Stephen R.} and Pearson, {Mark L.} and Lautenberger, {James A.} and Papas, {Takis S.} and John Ghrayeb and Chang, {Nancy T.} and Gallo, {Robert C.} and Flossie Wong-Staal",

year = "1985",

doi = "10.1038/313277a0",

language = "English",

volume = "313",

pages = "277--284",

journal = "Nature",

issn = "0028-0836",

number = "6000",

}

Ratner, L, Haseltine, W, Patarca, R, Livak, KJ, Starcich, B, Josephs, SF, Doran, ER, Rafalski, JA, Whitehorn, EA, Baumeister, K, Ivanoff, L, Petteway, SR, Pearson, ML, Lautenberger, JA, Papas, TS, Ghrayeb, J, Chang, NT, Gallo, RC & Wong-Staal, F 1985, 'Complete nucleotide sequence of the AIDS virus, HTLV-III', Nature, vol. 313, no. 6000, pp. 277-284. https://doi.org/10.1038/313277a0

TY - JOUR

T1 - Complete nucleotide sequence of the AIDS virus, HTLV-III

AU - Ratner, Lee

AU - Haseltine, William

AU - Patarca, Roberto

AU - Livak, Kenneth J.

AU - Starcich, Bruno

AU - Josephs, Steven F.

AU - Doran, Ellen R.

AU - Rafalski, J. Antoni

AU - Whitehorn, Erik A.

AU - Baumeister, Kirk

AU - Ivanoff, Lucinda

AU - Petteway, Stephen R.

AU - Pearson, Mark L.

AU - Lautenberger, James A.

AU - Papas, Takis S.

AU - Ghrayeb, John

AU - Chang, Nancy T.

AU - Gallo, Robert C.

AU - Wong-Staal, Flossie

PY - 1985

Y1 - 1985

N2 - The complete nucleotide sequence of two human T-cell leukaemia type III (HTLV-III) proviral DNAs each have four long open reading frames, the first two corresponding to the gag and pol genes. The fourth open reading frame encodes two functional polypeptides, a large precursor of the major envelope glycoprotein and a smaller protein derived from the 3′-terminus long open reading frame analogous to the long open reading frame (lor) product of HTLV-I and -II.

AB - The complete nucleotide sequence of two human T-cell leukaemia type III (HTLV-III) proviral DNAs each have four long open reading frames, the first two corresponding to the gag and pol genes. The fourth open reading frame encodes two functional polypeptides, a large precursor of the major envelope glycoprotein and a smaller protein derived from the 3′-terminus long open reading frame analogous to the long open reading frame (lor) product of HTLV-I and -II.

UR - http://www.scopus.com/inward/record.url?scp=0021912920&partnerID=8YFLogxK

U2 - 10.1038/313277a0

DO - 10.1038/313277a0

M3 - Article

C2 - 2578615

AN - SCOPUS:0021912920

SN - 0028-0836

VL - 313

SP - 277

EP - 284

JO - Nature

JF - Nature

IS - 6000

ER -

Complete nucleotide sequence of the AIDS virus, HTLV-III

Abstract

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