Complete nucleotide sequence of the AIDS virus, HTLV-III

Lee Ratner, William Haseltine, Roberto Patarca, Kenneth J. Livak, Bruno Starcich, Steven F. Josephs, Ellen R. Doran, J. Antoni Rafalski, Erik A. Whitehorn, Kirk Baumeister, Lucinda Ivanoff, Stephen R. Petteway, Mark L. Pearson, James A. Lautenberger, Takis S. Papas, John Ghrayeb, Nancy T. Chang, Robert C. Gallo, Flossie Wong-Staal

Research output: Contribution to journalArticlepeer-review

1684 Scopus citations

Abstract

The complete nucleotide sequence of two human T-cell leukaemia type III (HTLV-III) proviral DNAs each have four long open reading frames, the first two corresponding to the gag and pol genes. The fourth open reading frame encodes two functional polypeptides, a large precursor of the major envelope glycoprotein and a smaller protein derived from the 3′-terminus long open reading frame analogous to the long open reading frame (lor) product of HTLV-I and -II.

Original languageEnglish
Pages (from-to)277-284
Number of pages8
JournalNature
Volume313
Issue number6000
DOIs
StatePublished - Dec 1 1985
Externally publishedYes

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