Complete Mapping of Mutations to the SARS-CoV-2 Spike Receptor-Binding Domain that Escape Antibody Recognition

Allison J. Greaney; Tyler N. Starr; Pavlo Gilchuk; Seth J. Zost; Elad Binshtein; Andrea N. Loes; Sarah K. Hilton; John Huddleston; Rachel Eguia; Katharine H.D. Crawford; Adam S. Dingens; Rachel S. Nargi; Rachel E. Sutton; Naveenchandra Suryadevara; Paul W. Rothlauf; Zhuoming Liu; Sean P.J. Whelan; Robert H. Carnahan; James E. Crowe; Jesse D. Bloom

doi:10.1016/j.chom.2020.11.007

Complete Mapping of Mutations to the SARS-CoV-2 Spike Receptor-Binding Domain that Escape Antibody Recognition

Allison J. Greaney
, Tyler N. Starr
, Pavlo Gilchuk
, Seth J. Zost
, Elad Binshtein
, Andrea N. Loes
, Sarah K. Hilton
, John Huddleston
, Rachel Eguia
, Katharine H.D. Crawford
, Adam S. Dingens
, Rachel S. Nargi
, Rachel E. Sutton
, Naveenchandra Suryadevara
, Paul W. Rothlauf
, Zhuoming Liu
, Sean P.J. Whelan
, Robert H. Carnahan
, James E. Crowe
, Jesse D. Bloom

Research output: Contribution to journal › Article › peer-review

776 Scopus citations

Abstract

Greaney et al. develop a method to map all mutations to the SARS-CoV-2 RBD that escape antibody binding and apply this method to 10 antibodies. The resulting escape maps predict which mutations arise when virus is grown in the presence of antibody and can inform the design of antibody therapeutics.

Original language	English
Pages (from-to)	44-57.e9
Journal	Cell Host and Microbe
Volume	29
Issue number	1
DOIs	https://doi.org/10.1016/j.chom.2020.11.007
State	Published - Jan 13 2021

Keywords

SARS-CoV-2
antibody escape
antigenic evolution
deep mutational scanning

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10.1016/j.chom.2020.11.007

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Greaney, A. J., Starr, T. N., Gilchuk, P., Zost, S. J., Binshtein, E., Loes, A. N., Hilton, S. K., Huddleston, J., Eguia, R., Crawford, K. H. D., Dingens, A. S., Nargi, R. S., Sutton, R. E., Suryadevara, N., Rothlauf, P. W., Liu, Z., Whelan, S. P. J., Carnahan, R. H., Crowe, J. E., & Bloom, J. D. (2021). Complete Mapping of Mutations to the SARS-CoV-2 Spike Receptor-Binding Domain that Escape Antibody Recognition. Cell Host and Microbe, 29(1), 44-57.e9. https://doi.org/10.1016/j.chom.2020.11.007

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title = "Complete Mapping of Mutations to the SARS-CoV-2 Spike Receptor-Binding Domain that Escape Antibody Recognition",

abstract = "Greaney et al. develop a method to map all mutations to the SARS-CoV-2 RBD that escape antibody binding and apply this method to 10 antibodies. The resulting escape maps predict which mutations arise when virus is grown in the presence of antibody and can inform the design of antibody therapeutics.",

keywords = "SARS-CoV-2, antibody escape, antigenic evolution, deep mutational scanning",

author = "Greaney, \{Allison J.\} and Starr, \{Tyler N.\} and Pavlo Gilchuk and Zost, \{Seth J.\} and Elad Binshtein and Loes, \{Andrea N.\} and Hilton, \{Sarah K.\} and John Huddleston and Rachel Eguia and Crawford, \{Katharine H.D.\} and Dingens, \{Adam S.\} and Nargi, \{Rachel S.\} and Sutton, \{Rachel E.\} and Naveenchandra Suryadevara and Rothlauf, \{Paul W.\} and Zhuoming Liu and Whelan, \{Sean P.J.\} and Carnahan, \{Robert H.\} and Crowe, \{James E.\} and Bloom, \{Jesse D.\}",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors",

year = "2021",

month = jan,

day = "13",

doi = "10.1016/j.chom.2020.11.007",

language = "English",

volume = "29",

pages = "44--57.e9",

journal = "Cell Host and Microbe",

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Greaney, AJ, Starr, TN, Gilchuk, P, Zost, SJ, Binshtein, E, Loes, AN, Hilton, SK, Huddleston, J, Eguia, R, Crawford, KHD, Dingens, AS, Nargi, RS, Sutton, RE, Suryadevara, N, Rothlauf, PW, Liu, Z , Whelan, SPJ, Carnahan, RH, Crowe, JE & Bloom, JD 2021, 'Complete Mapping of Mutations to the SARS-CoV-2 Spike Receptor-Binding Domain that Escape Antibody Recognition', Cell Host and Microbe, vol. 29, no. 1, pp. 44-57.e9. https://doi.org/10.1016/j.chom.2020.11.007

TY - JOUR

T1 - Complete Mapping of Mutations to the SARS-CoV-2 Spike Receptor-Binding Domain that Escape Antibody Recognition

AU - Greaney, Allison J.

AU - Starr, Tyler N.

AU - Gilchuk, Pavlo

AU - Zost, Seth J.

AU - Binshtein, Elad

AU - Loes, Andrea N.

AU - Hilton, Sarah K.

AU - Huddleston, John

AU - Eguia, Rachel

AU - Crawford, Katharine H.D.

AU - Dingens, Adam S.

AU - Nargi, Rachel S.

AU - Sutton, Rachel E.

AU - Suryadevara, Naveenchandra

AU - Rothlauf, Paul W.

AU - Liu, Zhuoming

AU - Whelan, Sean P.J.

AU - Carnahan, Robert H.

AU - Crowe, James E.

AU - Bloom, Jesse D.

PY - 2021/1/13

Y1 - 2021/1/13

N2 - Greaney et al. develop a method to map all mutations to the SARS-CoV-2 RBD that escape antibody binding and apply this method to 10 antibodies. The resulting escape maps predict which mutations arise when virus is grown in the presence of antibody and can inform the design of antibody therapeutics.

AB - Greaney et al. develop a method to map all mutations to the SARS-CoV-2 RBD that escape antibody binding and apply this method to 10 antibodies. The resulting escape maps predict which mutations arise when virus is grown in the presence of antibody and can inform the design of antibody therapeutics.

KW - SARS-CoV-2

KW - antibody escape

KW - antigenic evolution

KW - deep mutational scanning

UR - https://www.scopus.com/pages/publications/85097068093

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DO - 10.1016/j.chom.2020.11.007

M3 - Article

C2 - 33259788

AN - SCOPUS:85097068093

SN - 1931-3128

VL - 29

SP - 44-57.e9

JO - Cell Host and Microbe

JF - Cell Host and Microbe

IS - 1

ER -

Complete Mapping of Mutations to the SARS-CoV-2 Spike Receptor-Binding Domain that Escape Antibody Recognition

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Keywords

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