Complete Mapping of Mutations to the SARS-CoV-2 Spike Receptor-Binding Domain that Escape Antibody Recognition

Allison J. Greaney, Tyler N. Starr, Pavlo Gilchuk, Seth J. Zost, Elad Binshtein, Andrea N. Loes, Sarah K. Hilton, John Huddleston, Rachel Eguia, Katharine H.D. Crawford, Adam S. Dingens, Rachel S. Nargi, Rachel E. Sutton, Naveenchandra Suryadevara, Paul W. Rothlauf, Zhuoming Liu, Sean P.J. Whelan, Robert H. Carnahan, James E. Crowe, Jesse D. Bloom

Research output: Contribution to journalArticlepeer-review

349 Scopus citations

Abstract

Greaney et al. develop a method to map all mutations to the SARS-CoV-2 RBD that escape antibody binding and apply this method to 10 antibodies. The resulting escape maps predict which mutations arise when virus is grown in the presence of antibody and can inform the design of antibody therapeutics.

Original languageEnglish
Pages (from-to)44-57.e9
JournalCell Host and Microbe
Volume29
Issue number1
DOIs
StatePublished - Jan 13 2021

Keywords

  • SARS-CoV-2
  • antibody escape
  • antigenic evolution
  • deep mutational scanning

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