Complete Hydatidiform Mole with a Coexisting Viable Male Fetus Detected by Cell-Free DNA

MacKenzie Lemieux, Lauren Kus, Kali Stewart, Mai He, Jackson Rowe, Matthew Brady, Katherine Bligard, Megan Lawlor, Jeannie Kelly

Research output: Contribution to journalArticlepeer-review

Abstract

Complete hydatidiform mole with coexisting fetus (CHMCF) is rare, and diagnosis is challenging due to limited data. Here, we present the case of a patient with noninvasive prenatal test (NIPT) resulting in likely molar pregnancy in the second trimester. Subsequent ultrasound confirmed a cystic appearing portion of the placenta. At 22 weeks, the patient delivered a demised fetus and two placentas. Pathology was consistent with CHMCF. This case is the first to show primary detection of a CHMCF with single-nucleotide polymorphism (SNP)-based NIPT prior to ultrasound identification. Our case suggests the use of SNP-based NIPT as an alternative noninvasive method to guide shared decision-making and clinical management for patients with this diagnosis.

Original languageEnglish
Pages (from-to)E49-E52
JournalAJP Reports
Volume13
Issue number3
DOIs
StatePublished - Jul 7 2023

Keywords

  • SNP-based
  • complete hydatidiform mole
  • molar pregnancy
  • noninvasive prenatal testing
  • twin pregnancy

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