Complete genome sequence of Le Blanc virus, a third Caenorhabditis nematode-infecting virus

Carl J. Franz, Guoyan Zhao, Marie Anne Félix, David Wang

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Orsay virus and Santeuil virus, the first known viruses capable of naturally infecting the nematodes Caenorhabditis elegansand Caenorhabditis briggsae, respectively, were recently identified by high-throughput sequencing of wild Caenorhabditis strains. Bysimilar analysis of another wild C. briggsae isolate, we have now discovered and sequenced the complete genome of a third novel virus, Le Blanc virus, that is distantly related to Orsay and Santeuil viruses. All three viruses are positive-sense RNA viruses with bipartite genomes that are most closely related to nodaviruses. Identification of a third virus capable of infecting Caenorhabditis nematodes enables comparative analysis of this clade of viruses and strengthens this model for investigating virus-host interactions.

Original languageEnglish
Pages (from-to)11940
Number of pages1
JournalJournal of virology
Volume86
Issue number21
DOIs
StatePublished - Nov 2012

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