TY - JOUR
T1 - Complementary diversification of dendritic cells and innate lymphoid cells
AU - Briseño, Carlos G.
AU - Murphy, Theresa L.
AU - Murphy, Kenneth M.
N1 - Funding Information:
The authors thank Vivek Durai, Ansuman T. Satpathy and Xiaodi Wu for their critical reading of the manuscript. Supported by the Howard Hughes Medical Institute (K.M.M.).
PY - 2014/8
Y1 - 2014/8
N2 - Dendritic cells (DCs) are professional antigen presenting cells conventionally thought to mediate cellular adaptive immune responses. Recent studies have led to the recognition of a non-redundant role for DCs in orchestrating innate immune responses, and in particular, for DC subset-specific interactions with innate lymphoid cells (ILCs). Recently recognized as important effectors of early immune responses, ILCs develop into subsets which mirror the transcriptional and cytokine profile of their T cell subset counterparts. DC diversification into functional subsets provides for modules of pathogen sensing and cytokine production that direct pathogen-appropriate ILC and T cell responses. This review focuses on the recent advances in the understanding of DC development, and their function in orchestrating the innate immune modules.
AB - Dendritic cells (DCs) are professional antigen presenting cells conventionally thought to mediate cellular adaptive immune responses. Recent studies have led to the recognition of a non-redundant role for DCs in orchestrating innate immune responses, and in particular, for DC subset-specific interactions with innate lymphoid cells (ILCs). Recently recognized as important effectors of early immune responses, ILCs develop into subsets which mirror the transcriptional and cytokine profile of their T cell subset counterparts. DC diversification into functional subsets provides for modules of pathogen sensing and cytokine production that direct pathogen-appropriate ILC and T cell responses. This review focuses on the recent advances in the understanding of DC development, and their function in orchestrating the innate immune modules.
UR - http://www.scopus.com/inward/record.url?scp=84901415239&partnerID=8YFLogxK
U2 - 10.1016/j.coi.2014.04.006
DO - 10.1016/j.coi.2014.04.006
M3 - Review article
C2 - 24874447
AN - SCOPUS:84901415239
SN - 0952-7915
VL - 29
SP - 69
EP - 78
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
IS - 1
ER -