Complementary detection of prostate-specific antigen using In 2O3 nanowires and carbon nanotubes

Chao Li; Marco Curreli; Henry Lin; Bo Lei; F. N. Ishikawa; Ram Datar; Richard J. Cote; Mark E. Thompson; Chongwu Zhou

doi:10.1021/ja053761g

Complementary detection of prostate-specific antigen using In ₂O₃ nanowires and carbon nanotubes

Chao Li, Marco Curreli, Henry Lin, Bo Lei, F. N. Ishikawa, Ram Datar, Richard J. Cote, Mark E. Thompson, Chongwu Zhou

Research output: Contribution to journal › Article › peer-review

384 Scopus citations

Abstract

We report complementary detection of prostate-specific antigen (PSA) using n-type In₂O₃ nanowires and p-type carbon nanotubes. Our innovation involves developing an approach to covalently attach antibodies to In₂O₃ NW surfaces via the onsite surface synthesis of phosphonic acid-succinylimide ester. Electronic measurements under dry conditions revealed complementary response for In₂O₃ NW and SWNT devices after the binding of PSA. Real-time detection in solution has also been demonstrated for PSA down to 5 ng/mL, a benchmark concentration significant for clinical diagnosis of prostate cancer, which is the most frequently diagnosed cancer.

Original language	English
Pages (from-to)	12484-12485
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	127
Issue number	36
DOIs	https://doi.org/10.1021/ja053761g
State	Published - Sep 14 2005

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abstract = "We report complementary detection of prostate-specific antigen (PSA) using n-type In2O3 nanowires and p-type carbon nanotubes. Our innovation involves developing an approach to covalently attach antibodies to In2O3 NW surfaces via the onsite surface synthesis of phosphonic acid-succinylimide ester. Electronic measurements under dry conditions revealed complementary response for In2O3 NW and SWNT devices after the binding of PSA. Real-time detection in solution has also been demonstrated for PSA down to 5 ng/mL, a benchmark concentration significant for clinical diagnosis of prostate cancer, which is the most frequently diagnosed cancer.",

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AU - Li, Chao

AU - Curreli, Marco

AU - Lin, Henry

AU - Lei, Bo

AU - Ishikawa, F. N.

AU - Datar, Ram

AU - Cote, Richard J.

AU - Thompson, Mark E.

AU - Zhou, Chongwu

PY - 2005/9/14

Y1 - 2005/9/14

N2 - We report complementary detection of prostate-specific antigen (PSA) using n-type In2O3 nanowires and p-type carbon nanotubes. Our innovation involves developing an approach to covalently attach antibodies to In2O3 NW surfaces via the onsite surface synthesis of phosphonic acid-succinylimide ester. Electronic measurements under dry conditions revealed complementary response for In2O3 NW and SWNT devices after the binding of PSA. Real-time detection in solution has also been demonstrated for PSA down to 5 ng/mL, a benchmark concentration significant for clinical diagnosis of prostate cancer, which is the most frequently diagnosed cancer.

AB - We report complementary detection of prostate-specific antigen (PSA) using n-type In2O3 nanowires and p-type carbon nanotubes. Our innovation involves developing an approach to covalently attach antibodies to In2O3 NW surfaces via the onsite surface synthesis of phosphonic acid-succinylimide ester. Electronic measurements under dry conditions revealed complementary response for In2O3 NW and SWNT devices after the binding of PSA. Real-time detection in solution has also been demonstrated for PSA down to 5 ng/mL, a benchmark concentration significant for clinical diagnosis of prostate cancer, which is the most frequently diagnosed cancer.

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JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 36

ER -

Complementary detection of prostate-specific antigen using In ₂O₃ nanowires and carbon nanotubes

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