Complement and its role in protection and pathogenesis of flavivirus infections

Panisadee Avirutnan; Erin Mehlhop; Michael S. Diamond

doi:10.1016/j.vaccine.2008.11.061

Complement and its role in protection and pathogenesis of flavivirus infections

Panisadee Avirutnan
, Erin Mehlhop
, Michael S. Diamond

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

The complement system is a family of serum and cell surface proteins that recognize pathogen-associated molecular patterns, altered-self ligands, and immune complexes. Activation of the complement cascade triggers several antiviral functions including pathogen opsonization and/or lysis, and priming of adaptive immune responses. In this review, we will examine the role of complement activation in protection and/or pathogenesis against infection by Flaviviruses, with an emphasis on experiments with West Nile and Dengue viruses.

Original language	English
Pages (from-to)	I100-I107
Journal	Vaccine
Volume	26
Issue number	SUPPL. 8
DOIs	https://doi.org/10.1016/j.vaccine.2008.11.061
State	Published - Dec 30 2008

Keywords

Virus, Innate Immunity, Dengue, West Nile, Immune Evasion

Access to Document

10.1016/j.vaccine.2008.11.061

Cite this

@article{988a7fd921d64daab7bb4e3a2cce2b26,

title = "Complement and its role in protection and pathogenesis of flavivirus infections",

abstract = "The complement system is a family of serum and cell surface proteins that recognize pathogen-associated molecular patterns, altered-self ligands, and immune complexes. Activation of the complement cascade triggers several antiviral functions including pathogen opsonization and/or lysis, and priming of adaptive immune responses. In this review, we will examine the role of complement activation in protection and/or pathogenesis against infection by Flaviviruses, with an emphasis on experiments with West Nile and Dengue viruses.",

keywords = "Virus, Innate Immunity, Dengue, West Nile, Immune Evasion",

author = "Panisadee Avirutnan and Erin Mehlhop and Diamond, \{Michael S.\}",

year = "2008",

month = dec,

day = "30",

doi = "10.1016/j.vaccine.2008.11.061",

language = "English",

volume = "26",

pages = "I100--I107",

journal = "Vaccine",

issn = "0264-410X",

number = "SUPPL. 8",

}

TY - JOUR

T1 - Complement and its role in protection and pathogenesis of flavivirus infections

AU - Avirutnan, Panisadee

AU - Mehlhop, Erin

AU - Diamond, Michael S.

PY - 2008/12/30

Y1 - 2008/12/30

N2 - The complement system is a family of serum and cell surface proteins that recognize pathogen-associated molecular patterns, altered-self ligands, and immune complexes. Activation of the complement cascade triggers several antiviral functions including pathogen opsonization and/or lysis, and priming of adaptive immune responses. In this review, we will examine the role of complement activation in protection and/or pathogenesis against infection by Flaviviruses, with an emphasis on experiments with West Nile and Dengue viruses.

AB - The complement system is a family of serum and cell surface proteins that recognize pathogen-associated molecular patterns, altered-self ligands, and immune complexes. Activation of the complement cascade triggers several antiviral functions including pathogen opsonization and/or lysis, and priming of adaptive immune responses. In this review, we will examine the role of complement activation in protection and/or pathogenesis against infection by Flaviviruses, with an emphasis on experiments with West Nile and Dengue viruses.

KW - Virus, Innate Immunity, Dengue, West Nile, Immune Evasion

UR - https://www.scopus.com/pages/publications/57649165055

U2 - 10.1016/j.vaccine.2008.11.061

DO - 10.1016/j.vaccine.2008.11.061

M3 - Article

C2 - 19388173

AN - SCOPUS:57649165055

SN - 0264-410X

VL - 26

SP - I100-I107

JO - Vaccine

JF - Vaccine

IS - SUPPL. 8

ER -

Complement and its role in protection and pathogenesis of flavivirus infections

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this