TY - JOUR
T1 - Complement and its role in protection and pathogenesis of flavivirus infections
AU - Avirutnan, Panisadee
AU - Mehlhop, Erin
AU - Diamond, Michael S.
PY - 2008/12/30
Y1 - 2008/12/30
N2 - The complement system is a family of serum and cell surface proteins that recognize pathogen-associated molecular patterns, altered-self ligands, and immune complexes. Activation of the complement cascade triggers several antiviral functions including pathogen opsonization and/or lysis, and priming of adaptive immune responses. In this review, we will examine the role of complement activation in protection and/or pathogenesis against infection by Flaviviruses, with an emphasis on experiments with West Nile and Dengue viruses.
AB - The complement system is a family of serum and cell surface proteins that recognize pathogen-associated molecular patterns, altered-self ligands, and immune complexes. Activation of the complement cascade triggers several antiviral functions including pathogen opsonization and/or lysis, and priming of adaptive immune responses. In this review, we will examine the role of complement activation in protection and/or pathogenesis against infection by Flaviviruses, with an emphasis on experiments with West Nile and Dengue viruses.
KW - Virus, Innate Immunity, Dengue, West Nile, Immune Evasion
UR - https://www.scopus.com/pages/publications/57649165055
U2 - 10.1016/j.vaccine.2008.11.061
DO - 10.1016/j.vaccine.2008.11.061
M3 - Article
C2 - 19388173
AN - SCOPUS:57649165055
SN - 0264-410X
VL - 26
SP - I100-I107
JO - Vaccine
JF - Vaccine
IS - SUPPL. 8
ER -