Complement and its role in protection and pathogenesis of flavivirus infections

Panisadee Avirutnan, Erin Mehlhop, Michael S. Diamond

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


The complement system is a family of serum and cell surface proteins that recognize pathogen-associated molecular patterns, altered-self ligands, and immune complexes. Activation of the complement cascade triggers several antiviral functions including pathogen opsonization and/or lysis, and priming of adaptive immune responses. In this review, we will examine the role of complement activation in protection and/or pathogenesis against infection by Flaviviruses, with an emphasis on experiments with West Nile and Dengue viruses.

Original languageEnglish
Pages (from-to)I100-I107
Issue numberSUPPL. 8
StatePublished - Dec 30 2008


  • Virus, Innate Immunity, Dengue, West Nile, Immune Evasion


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