Competitive Kinase Enrichment Proteomics Reveals that Abemaciclib Inhibits GSK3b and Activates WNT Signaling

Keyphrases

• Wnt Signaling 100%
• Proteomics 100%
• Glycogen Synthase kinase-3β (GSK-3β) 100%
• Abemaciclib 100%
• Kinase Enrichment 100%
• Multiplexing 66%
• Palbociclib 66%
• Cell-based 50%
• Kinase Inhibitor 50%
• Kinase Target 33%
• Small Molecule Kinase Inhibitors 33%
• Beta-catenin 33%
• Chemical Proteomics 33%
• Glycogen Synthase Kinase 3 (GSK3) 16%
• Mass Spectrometry Analysis 16%
• Dose-limiting Toxicity 16%
• Clinical Efficacy 16%
• In Vitro Kinase Assay 16%
• Mass Spectrometry 16%
• Dose-response 16%
• Cell Lysate 16%
• Quantitative Proteomics 16%
• Proteomic Approach 16%
• Kinase Activity 16%
• Living Cells 16%
• Trametinib 16%
• Nanomolar Concentrations 16%
• Target Specificity 16%
• Mass Spectrometry Profiling 16%
• CaMKII 16%
• Phenotypic Response 16%
• Drug Repurposing 16%
• Cyclin-dependent Kinase 4/6 Inhibitors 16%
• Dasatinib 16%
• Kinome Profiling 16%
• Ribociclib 16%
• Competition Analysis 16%
• Mass Spectrometry Platform 16%
• BMS-777607 16%

Biochemistry, Genetics and Molecular Biology

• Kinase 100%
• Phosphotransferase 100%
• Proteomics 100%
• Mass Spectrometry 30%
• Catenin 20%
• Small Molecule 20%
• Glycogen Synthase Kinase 3 10%
• Protein Kinases 10%
• Cell Lysate 10%
• Mass Spectrometry 10%
• Quantitative Proteomics 10%
• Cyclin-Dependent Kinase 4 10%
• Kinome 10%
• Dasatinib 10%
• Cyclin-Dependent Kinase 6 10%
• Calmodulin 10%
• Trametinib 10%