@article{895ccfbcb9a94f56bfd05a1f899e2d2a,
title = "Compensatory dendritic cell development mediated by BATF-IRF interactions",
abstract = "The AP1 transcription factor Batf3 is required for homeostatic development of CD8α + classical dendritic cells that prime CD8 T-cell responses against intracellular pathogens. Here we identify an alternative, Batf3-independent pathway in mice for CD8α + dendritic cell development operating during infection with intracellular pathogens and mediated by the cytokines interleukin (IL)-12 and interferon-γ. This alternative pathway results from molecular compensation for Batf3 provided by the related AP1 factors Batf, which also functions in T and B cells, and Batf2 induced by cytokines in response to infection. Reciprocally, physiological compensation between Batf and Batf3 also occurs in T cells for expression of IL-10 and CTLA4. Compensation among BATF factors is based on the shared capacity of their leucine zipper domains to interact with non-AP1 factors such as IRF4 and IRF8 to mediate cooperative gene activation. Conceivably, manipulating this alternative pathway of dendritic cell development could be of value in augmenting immune responses to vaccines.",
author = "Roxane Tussiwand and Lee, {Wan Ling} and Murphy, {Theresa L.} and Mona Mashayekhi and Wumesh Kc and Albring, {J{\"o}rn C.} and Satpathy, {Ansuman T.} and Rotondo, {Jeffrey A.} and Edelson, {Brian T.} and Kretzer, {Nicole M.} and Xiaodi Wu and Weiss, {Leslie A.} and Elke Glasmacher and Peng Li and Wei Liao and Michael Behnke and Lam, {Samuel S.K.} and Aurthur, {Cora T.} and Leonard, {Warren J.} and Harinder Singh and Stallings, {Christina L.} and {David Sibley}, L. and Schreiber, {Robert D.} and Murphy, {Kenneth M.}",
note = "Funding Information: AcknowledgementsThisworkwas supported bythe Howard HughesMedicalInstitute, National Institutes of Health (AI076427-02) and Department of Defense (W81XWH-09-1-0185) (K.M.M.), the American Heart Association (12PRE8610005) (A.T.S.), German Research Foundation (AL 1038/1-1) (J.C.A), American Society of Hematology Scholar Award and Burroughs Welcome Fund Career Award for Medical Scientists (B.T.E.), and Cancer Research Institute predoctoral fellowship (W.-L.L.). We thank the ImmGen consortium34, M. White for blastocyst injections and generation of mouse chimaeras, the Alvin J. Siteman Cancer Center at Washington University School of Medicine for use of the Center for Biomedical Informatics and Multiplex Gene Analysis Genechip Core Facility. The Siteman Cancer Center is supported in part by the NCI Cancer Center Support Grant P30 CA91842. IL-12 was a gift from Pfizer.",
year = "2012",
month = oct,
day = "25",
doi = "10.1038/nature11531",
language = "English",
volume = "490",
pages = "502--507",
journal = "Nature",
issn = "0028-0836",
number = "7421",
}