Compendium of genome-wide scans of lipid-related phenotypes: Adding a new genome-wide search of apolipoprotein levels

Yohan Bossé, Yvon C. Chagnon, Jean Pierre Després, Treva Rice, D. C. Rao, Claude Bouchard, Louis Pérusse, Marie Claude Vohl

Research output: Contribution to journalReview article

27 Scopus citations

Abstract

The genetic dissection of complex inherited diseases is a major challenge. Despite limited success in finding genes, substantial data based on genome-wide scan strategies is now available for a variety of diseases and related phenotypes. This can perhaps best be appreciated in the field of lipid and lipoprotein levels, where the amount of information generated is becoming overwhelming. We have created a data-base containing the results from whole-genome scans of lipid-related phenotypes undertaken to date. The usefulness of this database is demonstrated by performing a new autosomal genomic scan on apolipoprotein B (apoB), LDL-apoB, and apoA-I levels, measured in 679 subjects of 243 nuclear families. Linkage was tested using both allele-sharing and variance-component methods. Only two loci provided support for linkage with both methods: a LDL-apoB locus on 18q21.32 and an apoA-I locus on 3p25.2. Adding those findings to the database highlighted the fact that the former is reported as a lipid-related locus for the first time, whereas the latter has been observed before. However, concerns arise when displaying all data on the same map, because a large portion of the genome is now covered with loci supported by at least suggestive evidence of linkage.

Original languageEnglish
Pages (from-to)2174-2184
Number of pages11
JournalJournal of lipid research
Volume45
Issue number12
DOIs
StatePublished - Dec 1 2004

Keywords

  • Cardiovascular risk factors
  • Dyslipidemia
  • Linkage
  • Lipoproteins
  • Quantitative trait locus

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