Comparisons between the structures of HCV and Rep helicases reveal structural similarities between SF1 and SF2 super-families of helicases

Sergey Korolev, Nanhua Yao, Timothy M. Lohman, Patricia C. Weber, Gabriel Waksman

Research output: Contribution to journalArticle

99 Scopus citations

Abstract

Three helicase structures have been determined recently: that of the DNA helicase PcrA, that of the hepatitis C virus RNA helicase, and that of the Escherichia coli DNA helicase Rep. PcrA and Rep belong to the same super- family of helicases (SF1) and are structurally very similar. In contrast, the HCV helicase belongs to a different super-family of helicases, SF2, and shows little sequence homology with the PcrA/Rep helicases. Yet, the HCV helicase is structurally similar to Rep/PcrA, suggesting preservation of structural scaffolds and relationships between helicase motifs across these two super- families. The comparison study presented here also reveals the existence of a new helicase motif in the SF1 family of helicases.

Original languageEnglish
Pages (from-to)605-610
Number of pages6
JournalProtein Science
Volume7
Issue number3
DOIs
StatePublished - Mar 1998

Keywords

  • HCV
  • Helicase motif
  • Rep
  • Structure

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