TY - JOUR
T1 - Comparison of values of antibody to bordetella pertussis antigens in young German and American Men
AU - Cherry, James D.
AU - Beer, Thomas
AU - Chartrand, Stephen A.
AU - De Ville, Jaime
AU - Beer, Elizabeth
AU - Olsen, Margaret A.
AU - Dermody, Peter D.
AU - Moore, Catherine V.
AU - Stehr, Klemens
N1 - Funding Information:
Received 9 August 1994; revised 25 October 1994. Financial support: This study was supported in part by a grant from Lederle-Praxis Biologicals and by a contract from the National Institute of Allergy and Infectious Diseases (NO 1-A 1 15124). Reprints or correspondence: Dr. James D. Cherry, Department of Pediatrics, UCLA School of Medicine, 22-442 MDCC, 10833 Le Conte Avenue, Los Angeles, California 90024.
PY - 1995/5
Y1 - 1995/5
N2 - Pertussis is well controlled in the United States by routine childhood immunization. In contrast, this disease is endemic and epidemic in Germany because routine immunization has not been implemented. To gain information relating to the epidemiology of Bordetella pertussis infections, we examined the prevalence and magnitude of B. pertussis agglutinins and of IgG and IgA antibodies (detected by enzyme-linked immunosorbent assay) to four B. pertussis antigens– lymphocytosis-promoting factor, filamentous hemagglutinin, pertactin, and fimbriae-2—in the sera of 119 American university students and 119 German military recruits of similar age. Geometric mean titers of agglutinins and geometric mean values for IgG antibodies to the four antigens were two- to threefold higher in sera from the American students than in sera from German recruits. In contrast, the geometric mean IgA values and the percentage of subjects with detectable IgA antibodies to the four antigens were similar in the two populations. Since IgA antibody results mainly from infection and not from immunization, our data suggest that B. pertussis infections are common among both American and German young adults despite the marked difference in rates of clinical pertussis in the two countries.
AB - Pertussis is well controlled in the United States by routine childhood immunization. In contrast, this disease is endemic and epidemic in Germany because routine immunization has not been implemented. To gain information relating to the epidemiology of Bordetella pertussis infections, we examined the prevalence and magnitude of B. pertussis agglutinins and of IgG and IgA antibodies (detected by enzyme-linked immunosorbent assay) to four B. pertussis antigens– lymphocytosis-promoting factor, filamentous hemagglutinin, pertactin, and fimbriae-2—in the sera of 119 American university students and 119 German military recruits of similar age. Geometric mean titers of agglutinins and geometric mean values for IgG antibodies to the four antigens were two- to threefold higher in sera from the American students than in sera from German recruits. In contrast, the geometric mean IgA values and the percentage of subjects with detectable IgA antibodies to the four antigens were similar in the two populations. Since IgA antibody results mainly from infection and not from immunization, our data suggest that B. pertussis infections are common among both American and German young adults despite the marked difference in rates of clinical pertussis in the two countries.
UR - https://www.scopus.com/pages/publications/0029035345
U2 - 10.1093/clinids/20.5.1271
DO - 10.1093/clinids/20.5.1271
M3 - Article
C2 - 7620009
AN - SCOPUS:0029035345
SN - 1058-4838
VL - 20
SP - 1271
EP - 1274
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 5
ER -