TY - JOUR
T1 - Comparison of the two types of immunoglobulin-bearing lymphocytes in human blood with regard to capping and motility
AU - Ault, Kenneth A.
AU - Unanue, Emil R.
N1 - Funding Information:
The authors appreciate the helpful comments and suggestions course of this work and the skillful technical assistance of Murray This work was supported by National Institutes of Health Grant Institute Grant 14723.
PY - 1977/5
Y1 - 1977/5
N2 - Human blood lymphocytes contain two populations of immunoglobulin-bearing cells. One has passively acquired, labile IgG on its surface, is not phagocytic, and does not contain detectable peroxidase. It also does not show capping or stimulation of motility after binding anti-IgG antibody. The other population of true B cells has IgM and IgD on its surface, most cells having both. This population behaves as conventional B lymphocytes, showing capping and anti-immunoglobulin-stimulated motility. The capping is independent of cell motility and cannot be inhibited by colchicine. The effects of anti-IgM and anti-IgD on these cells are similar in that they both stimulate capping and motility to about the same extent and both cap to the same region of the cell surface.
AB - Human blood lymphocytes contain two populations of immunoglobulin-bearing cells. One has passively acquired, labile IgG on its surface, is not phagocytic, and does not contain detectable peroxidase. It also does not show capping or stimulation of motility after binding anti-IgG antibody. The other population of true B cells has IgM and IgD on its surface, most cells having both. This population behaves as conventional B lymphocytes, showing capping and anti-immunoglobulin-stimulated motility. The capping is independent of cell motility and cannot be inhibited by colchicine. The effects of anti-IgM and anti-IgD on these cells are similar in that they both stimulate capping and motility to about the same extent and both cap to the same region of the cell surface.
UR - http://www.scopus.com/inward/record.url?scp=0017626031&partnerID=8YFLogxK
U2 - 10.1016/0090-1229(77)90074-5
DO - 10.1016/0090-1229(77)90074-5
M3 - Article
C2 - 326451
AN - SCOPUS:0017626031
SN - 0090-1229
VL - 7
SP - 394
EP - 404
JO - Clinical Immunology and Immunopathology
JF - Clinical Immunology and Immunopathology
IS - 3
ER -