Comparison of the host responses to wild-type and cpsB mutant Klebsiella pneumoniae infections

Matthew S. Lawlor; Scott A. Handley; Virginia L. Miller

doi:10.1128/IAI.00244-06

Comparison of the host responses to wild-type and cpsB mutant Klebsiella pneumoniae infections

Matthew S. Lawlor, Scott A. Handley, Virginia L. Miller

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53 Scopus citations

Abstract

Previously, we established an intranasal mouse model of Klebsiella pneumoniae infection and validated its utility using a highly virulent wild-type strain and an avirulent capsular polysaccharide mutant. In the present study we compare the host responses to both infections by examining cytokine production, cellular infiltration, pulmonary histology, and intranasal immunization.

Original language	English
Pages (from-to)	5402-5407
Number of pages	6
Journal	Infection and immunity
Volume	74
Issue number	9
DOIs	https://doi.org/10.1128/IAI.00244-06
State	Published - Sep 2006

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abstract = "Previously, we established an intranasal mouse model of Klebsiella pneumoniae infection and validated its utility using a highly virulent wild-type strain and an avirulent capsular polysaccharide mutant. In the present study we compare the host responses to both infections by examining cytokine production, cellular infiltration, pulmonary histology, and intranasal immunization.",

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AB - Previously, we established an intranasal mouse model of Klebsiella pneumoniae infection and validated its utility using a highly virulent wild-type strain and an avirulent capsular polysaccharide mutant. In the present study we compare the host responses to both infections by examining cytokine production, cellular infiltration, pulmonary histology, and intranasal immunization.

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Comparison of the host responses to wild-type and cpsB mutant Klebsiella pneumoniae infections

Abstract

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