Comparison of the host responses to wild-type and cpsB mutant Klebsiella pneumoniae infections

Matthew S. Lawlor, Scott A. Handley, Virginia L. Miller

Research output: Contribution to journalArticlepeer-review

58 Scopus citations

Abstract

Previously, we established an intranasal mouse model of Klebsiella pneumoniae infection and validated its utility using a highly virulent wild-type strain and an avirulent capsular polysaccharide mutant. In the present study we compare the host responses to both infections by examining cytokine production, cellular infiltration, pulmonary histology, and intranasal immunization.

Original languageEnglish
Pages (from-to)5402-5407
Number of pages6
JournalInfection and immunity
Volume74
Issue number9
DOIs
StatePublished - Sep 2006

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