Comparison of the behavior of natural and refilled porcine lenses in a robotic lens stretcher

Matthew A. Reilly, Paul D. Hamilton, Gavin Perry, Nathan Ravi

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

The mechanism by which the eye dynamically changes focal distance (accommodation), and the mechanism by which this ability is lost with age (presbyopia), are still contested. Due to inherent confounding factors in vivo, in vitro measurements have been undertaken using a robotic lens stretcher to examine these mechanisms as well as the efficacy of lens refilling - a proposed treatment for presbyopia. Dynamic forces, anterior and posterior curvatures, and lens thickness are all correlated for young natural and refilled porcine lenses. Comparisons are made to lenses refilled with a homogeneous polymer system. The amplitude of accommodation of the young porcine lens is very small such that it may be a suitable model for presbyopia. The behavior of refilled lenses was highly dependent on the refill volume. The volume could be tuned to maximize accommodative amplitude in the refilled lens.

Original languageEnglish
Pages (from-to)483-494
Number of pages12
JournalExperimental eye research
Volume88
Issue number3
DOIs
StatePublished - Mar 1 2009

Keywords

  • accommodation
  • accommodation forces
  • cataract
  • lens
  • lens curvature
  • lens stretching
  • optomechanics
  • presbyopia

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