Comparison of soft tissue effects of conventional ionic, low osmolar ionic and nonionic iodine containing contrast material in experimental animals

W. H. McAlister, J. M. Kissane

Research output: Contribution to journalArticlepeer-review

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Abstract

Conventional, low osmolar, and non-ionic iodine containing contrast media and saline controls were placed in the paws, muscles, and subcutaneous tissues of Sprague-Dawley rat thighs. The paw injections were observed and photographed, while the thighs were examined histologically. Results showed that although the low osmolar and non-ionic agents did produce inflammatory reactions and focal necrosis in the soft tissues, they were much better tolerated than were the conventional ionic agents. A non-ionic or low osmolar ionic contrast agent should be strongly considered when a possibility for extravasation exists.

Original languageEnglish
Pages (from-to)170-174
Number of pages5
JournalPediatric radiology
Volume20
Issue number3
DOIs
StatePublished - Jan 1 1990

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