Comparison of In-111-labeled platelets and iodinated fibrinogen for the detection of deep vein thrombosis

L. C. Knight, J. L. Primeau, B. A. Siegel, M. J. Welch

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

Indium-111-labeled platelets and I-125 fibrinogen were administered to dogs with experimentally induced deep-vein thrombosis. The thrombus uptake of both labeled compounds was studied as a function of thrombus age. In thrombi less than 24 hr old, thrombus-to-blood ratios for In-111 platelets were about twice as great as those obtained for I-125 fibrinogen. Excellent scintiphotos were obtained with In-111 platelets. In thrombi older than 24 hr, uptake of both agents was low, but good images were still obtained with In-111 platelets. The images in this case are not of thrombi, but rather of damaged vessel wall. Indium-111-labeled platelets are superior to iodinated fibrinogen for imaging fresh thrombi, but offer no advantage for thrombi over 24 hr old.

Original languageEnglish
Pages (from-to)891-894
Number of pages4
JournalJournal of Nuclear Medicine
Volume19
Issue number8
StatePublished - Jan 1 1978

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