Comparison of four bifunctional chelates for radiolabeling monoclonal antibodies with copper radioisotopes: Biodistribution and metabolism

Engineering & Materials Science

• Acids 16%
• Animals 17%
• Antibodies 11%
• Benzoic acid 30%
• Chelation 14%
• Copper 36%
• Labels 7%
• Liver 54%
• Metabolism 57%
• Metabolites 49%
• Molecular weight 20%
• Monoclonal antibodies 71%
• Proteins 8%
• Radioisotopes 56%
• Rats 32%
• Superoxide Dismutase 17%
• Tumors 18%

Medicine & Life Sciences

• 2-(4-chlorophenylthio)triethylamine 77%
• 4-((1,4,8,11-tetraazacyclotetradec-1-yl)methyl)benzoic acid 16%
• Acids 13%
• Animal Models 6%
• Animals 4%
• Benzoic Acid 12%
• Chelating Agents 10%
• Colonic Neoplasms 8%
• Copper 9%
• Copper Radioisotopes 100%
• Cricetinae 9%
• cyclam 35%
• Cyclams 35%
• Immunoglobulin Fragments 11%
• Injections 10%
• Kidney 19%
• Liver 23%
• Lysine 8%
• Mesocricetus 11%
• Molecular Weight 15%
• Monoclonal Antibodies 33%
• Neoplasms 5%
• Proteins 3%
• Sprague Dawley Rats 7%
• Superoxide Dismutase 8%

Chemical Compounds

• 1,4,8,11-tetraazacyclotetradecane 18%
• Acid 4%
• Chelating Agent 6%
• Label 5%
• Lipophilicity 6%
• Metabolite 18%
• Methylbenzoic Acid 21%
• Pharmacological Metabolism 35%
• Protein 2%
• Radioisotope 49%
• Retention Time 5%
• Superoxide 6%
• Weight 6%