Abstract
Background and purpose: Dose effects of intrafraction motion during prone prostate radiotherapy are unknown. We compared prone and supine treatment using real-time tracking data to model dose coverage. Material and methods: Electromagnetic tracking data were analyzed for 10 patients treated prone, and 15 treated supine, with IMRT for localized prostate cancer. Plans were generated using 0 mm, 3 mm, and 5 mm PTV expansions. Manual beam-hold interventions were applied to reposition the patient when translations exceeded a predetermined threshold. A custom software application (SWIFTER) used intrafraction tracking data acquired during beam-on model delivered prostate dose, by applying rigid body transformations to the prostate structure contoured at simulation within the planned dose cloud. The delivered minimum prostate dose as a percentage of planned dose (Dmin%), and prostate volume covered by the prescription dose as a percentage of the planned volume (VRx%) were compared for prone and supine treatment. Results: Dmin% was reduced for prone treatment for 0 (p = 0.02) and 3 mm (p = 0.03) PTV margins. VRx% was reduced for prone treatment only for 0 mm margins (p = 0.002). No significant differences were found using 5 mm margins. Conclusions: Intrafraction motion has a greater impact on target coverage for prone compared to supine prostate radiotherapy. PTV margins of 3 mm or less correlate with a significant decrease in delivered dose for prone treatment.
Original language | English |
---|---|
Pages (from-to) | 199-204 |
Number of pages | 6 |
Journal | Radiotherapy and Oncology |
Volume | 104 |
Issue number | 2 |
DOIs | |
State | Published - Aug 2012 |
Keywords
- Calypso
- Prone
- Prostate
- Radiotherapy
- Tracking