Comparison of brain structural variables, neuropsychological factors, and treatment outcome in early-onset versus late-onset late-life depression

Brianne M. Disabato, Carrie Morris, Jennifer Hranilovich, Gina M. D'Angelo, Gongfu Zhou, Ningying Wu, P. Murali Doraiswamy, Yvette I. Sheline

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Objective To compare differences in gray matter volumes, white matter and subcortical gray matter hyperintensities, neuropsychological factors, and treatment outcome between early-and late-onset late-life depressed (LLD) subjects. Methods We conducted a prospective, nonrandomized, controlled trial at the outpatient clinics at Washington University and Duke University on 126 subjects, aged 60 years or older, who met Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria for major depression, scored 20 or more on the Montgomery-Asberg Depression Rating Scale (MADRS), and received neuropsychological testing and magnetic resonance imaging. Subjects were excluded for cognitive impairment or severe medical disorders. After 12 weeks of sertraline treatment, subjects' MADRS scores over time and neuropsychological factors were studied. Results Left anterior cingulate thickness was significantly smaller in the late-onset depressed group than in the early-onset LLD subjects. The late-onset group also had more hyperintensities than the early-onset LLD subjects. No differences were found in neuropsychological factor scores or treatment outcome between early-onset and late-onset LLD subjects. Conclusion Age at onset of depressive symptoms in LLD subjects are associated with differences in cortical thickness and white matter and subcortical gray matter hyperintensities, but age at onset did not affect neuropsychological factors or treatment outcome.

Original languageEnglish
Pages (from-to)1039-1046
Number of pages8
JournalAmerican Journal of Geriatric Psychiatry
Volume22
Issue number10
DOIs
StatePublished - Oct 1 2014

Keywords

  • Late-life depression
  • age at onset
  • amygdala
  • antidepressant
  • cognitive deficit
  • hippocampus
  • neuropsychological factors
  • treatment outcome
  • vascular risk factors
  • white matter hyperintensities

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