Poredenje analgetskog efekta intratekalno primenjenog morfina samog ili u kombinaciji sa bupivakainom i fentanilom kod bolesnika podvrgnutih totalnoj gastrektomiji - prospektivna, randomizovana, dvostruko slepa klinička studija: A prospective randomized, double blind clinical trial

Translated title of the contribution: Comparison of analgesic effect of intrathecal morphine alone or in combination with bupivacaine and fentanyl in patients undergoing total gastrectomy: A prospective randomized, double blind clinical trial

Zoran Slavković, Dušica M. Stamenković, Veselin Gerić, Milić Veljović, Nebojša Ivanović, Aleksandar Tomić, Tomislav Randjelović, Jelena Rašković, Menelaos Karanikolas

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Background/Aim. Combined spinal-epidural-general anesthesia has several advantages over general anesthesia alone. This study was designed to compare the efficacy of intrathecal (IT) morphine alone, or in combination with bupivacaine and fentanyl, as part of a combined spinal-epidural (CSE) analgesia, in patients undergoing elective total gastrectomy. Methods. This prospective, randomized double-blind study included 60 patients undergoing total gastrectomy under general anesthesia and CSE. We compared the analgesic effect of lumbar IT morphine 300 μg (the group M, n = 20) vs morphine 300 μag + bupivacaine 2 mg (the group MB, n = 20) vs morphine 300 μg + bupivacaine 2 mg + fentanyl 25 μg (the group MBF, n = 20) given after thoracic epidural catheter placement (T6-7) but before general anesthesia induction. Pain visual analogue scale (VAS) at rest (R), with movement (M) and with cough (C), and the number of analgesia requests were assessed for 72 h and after epidural catheter removal. Results. Compared to other groups, the MBF group required significantly fewer additional intra-operative epidural bupivacaine doses (p < 0.001), whereas the M group required significantly more supplemental intraoperative intravenous fentanyl, compared with the MBF (p = 0.022) and MB groups (p = 0.005). Postoperative pain relief was satisfactory in all the groups at all the time. VAS-R and VAS-M did not differ significantly among the groups. Compared to the M group, VAS-C scores 30 min postoperatively were significantly lower in the MBF (p = 0.029) and MB groups (p = 0.002). Duration of analgesia was longer in the MBF and MB groups, but the difference reached no significance. The number of supplemental analgesia requests was similar in all the groups in the first 12 h and during 72 h. Additional analgesia requests after epidural catheter removal were similar in all the groups, and side effects were infrequent. Conclusion. Compared to IT morphine alone, triple IT combination administered as part of CSE provided better intraoperative analgesia, but conferred no benefit with regards to postoperative analgesia.

Translated title of the contributionComparison of analgesic effect of intrathecal morphine alone or in combination with bupivacaine and fentanyl in patients undergoing total gastrectomy: A prospective randomized, double blind clinical trial
Original languageUndefined/Unknown
Pages (from-to)541-547
Number of pages7
JournalVojnosanitetski Pregled
Volume70
Issue number6
DOIs
StatePublished - Jun 2013

Keywords

  • Analgesia
  • Anesthesia
  • Bupivacaine
  • Epidural
  • Fentanyl
  • Gastrectomy
  • Methods
  • Morphine
  • Spinal

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