TY - JOUR
T1 - Comparison of accelerated partial breast irradiation via multicatheter interstitial brachytherapy versus whole breast radiation
AU - Ferraro, Daniel J.
AU - Garsa, Adam A.
AU - DeWees, Todd A.
AU - Margenthaler, Julie A.
AU - Naughton, Michael
AU - Aft, Rebecca
AU - Gillanders, William E.
AU - Eberlein, Timothy
AU - Matesa, Melissa A.
AU - Zoberi, Imran
N1 - Funding Information:
We thank the SCC-WUSM and Barnes-Jewish Hospital in St. Louis, Mo., for the use of the Clinical Trials Core, which provided regulatory service. The Siteman Cancer Center is supported in part by NCI Cancer Center Support Grant #P30 CA91842. A portion of the data contained in this manuscript was presented at the ASTRO 52nd annual meeting.
PY - 2012/3/29
Y1 - 2012/3/29
N2 - Background: Brachytherapy as adjuvant treatment for early-stage breast cancer has become widely available and offers patients an expedited treatment schedule. Given this, many women are electing to undergo brachytherapy in lieu of standard fractionation radiotherapy. We compare outcomes between patients treated with accelerated partial breast irradiation (APBI) via multicatheter interstitial brachytherapy versus patients who were also eligible for and offered APBI but who chose whole breast radiation (WBI).Methods: Patients treated from December 2002 through May 2007 were reviewed. Selection criteria included patients with pTis-T2N0 disease, ≤ 3 cm unifocal tumors, and negative margins who underwent breast conservation surgery. Local control (LC), cause-specific (CSS) and overall survival (OS) were analyzed.Results: 202 patients were identified in the APBI cohort and 94 patients in the WBI cohort. Median follow-up for both groups exceeded 60 months. LC was 97.0% for the APBI cohort and 96.2% for the WBI cohort at 5 years (ns). Classification by 2010 ASTRO APBI consensus statement categories did not predict worse outcomes.Conclusion: APBI via multicatheter interstitial brachytherapy provides similar local failure rates compared to WBI at 5 years for properly selected patients. Excellent results were seen despite the high fraction of younger patients (< 60 years old) and patients with DCIS.
AB - Background: Brachytherapy as adjuvant treatment for early-stage breast cancer has become widely available and offers patients an expedited treatment schedule. Given this, many women are electing to undergo brachytherapy in lieu of standard fractionation radiotherapy. We compare outcomes between patients treated with accelerated partial breast irradiation (APBI) via multicatheter interstitial brachytherapy versus patients who were also eligible for and offered APBI but who chose whole breast radiation (WBI).Methods: Patients treated from December 2002 through May 2007 were reviewed. Selection criteria included patients with pTis-T2N0 disease, ≤ 3 cm unifocal tumors, and negative margins who underwent breast conservation surgery. Local control (LC), cause-specific (CSS) and overall survival (OS) were analyzed.Results: 202 patients were identified in the APBI cohort and 94 patients in the WBI cohort. Median follow-up for both groups exceeded 60 months. LC was 97.0% for the APBI cohort and 96.2% for the WBI cohort at 5 years (ns). Classification by 2010 ASTRO APBI consensus statement categories did not predict worse outcomes.Conclusion: APBI via multicatheter interstitial brachytherapy provides similar local failure rates compared to WBI at 5 years for properly selected patients. Excellent results were seen despite the high fraction of younger patients (< 60 years old) and patients with DCIS.
UR - http://www.scopus.com/inward/record.url?scp=84858964612&partnerID=8YFLogxK
U2 - 10.1186/1748-717X-7-53
DO - 10.1186/1748-717X-7-53
M3 - Article
C2 - 22458887
AN - SCOPUS:84858964612
SN - 1748-717X
VL - 7
JO - Radiation oncology (London, England)
JF - Radiation oncology (London, England)
IS - 1
M1 - 53
ER -