Comparison in animal models of 18F-spiroperidol and 18F-haloperidol: Potential agents for imaging the dopamine receptor

Michael J. Welch, Michael R. Kilbourn, Carla J. Mathias, Mark A. Mintun, Marcus E. Raichle

Research output: Contribution to journalArticlepeer-review

52 Scopus citations


Fluorine-18-labeled haloperidol and spiroperidol have been prepared by an exchange reaction using the corresponding non-labeled compound or the nitro analog. Studies in rats have shown that the distribution of labeled spiroperidol has a high striatum to cerebellum ratio which is not observed with haloperidol. A ratio of 10.66 ± 1.6 is obtained two hours after administration of the 18F-spiroperidol. When 18F-spiroperidol was administered to a baboon and tomographic images obtained, the dopamine receptor rich areas were clearly visualized two hours after administration.

Original languageEnglish
Pages (from-to)1687-1693
Number of pages7
JournalLife Sciences
Issue number17
StatePublished - Oct 24 1983

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