Abstract
Fluorine-18-labeled haloperidol and spiroperidol have been prepared by an exchange reaction using the corresponding non-labeled compound or the nitro analog. Studies in rats have shown that the distribution of labeled spiroperidol has a high striatum to cerebellum ratio which is not observed with haloperidol. A ratio of 10.66 ± 1.6 is obtained two hours after administration of the 18F-spiroperidol. When 18F-spiroperidol was administered to a baboon and tomographic images obtained, the dopamine receptor rich areas were clearly visualized two hours after administration.
Original language | English |
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Pages (from-to) | 1687-1693 |
Number of pages | 7 |
Journal | Life Sciences |
Volume | 33 |
Issue number | 17 |
DOIs | |
State | Published - Oct 24 1983 |