Comparison in animal models of 18F-spiroperidol and 18F-haloperidol: Potential agents for imaging the dopamine receptor

Michael J. Welch; Michael R. Kilbourn; Carla J. Mathias; Mark A. Mintun; Marcus E. Raichle

doi:10.1016/0024-3205(83)90725-7

Comparison in animal models of ¹⁸F-spiroperidol and ¹⁸F-haloperidol: Potential agents for imaging the dopamine receptor

Michael J. Welch, Michael R. Kilbourn, Carla J. Mathias, Mark A. Mintun, Marcus E. Raichle

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

Fluorine-18-labeled haloperidol and spiroperidol have been prepared by an exchange reaction using the corresponding non-labeled compound or the nitro analog. Studies in rats have shown that the distribution of labeled spiroperidol has a high striatum to cerebellum ratio which is not observed with haloperidol. A ratio of 10.66 ± 1.6 is obtained two hours after administration of the ¹⁸F-spiroperidol. When ¹⁸F-spiroperidol was administered to a baboon and tomographic images obtained, the dopamine receptor rich areas were clearly visualized two hours after administration.

Original language	English
Pages (from-to)	1687-1693
Number of pages	7
Journal	Life Sciences
Volume	33
Issue number	17
DOIs	https://doi.org/10.1016/0024-3205(83)90725-7
State	Published - Oct 24 1983

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title = "Comparison in animal models of 18F-spiroperidol and 18F-haloperidol: Potential agents for imaging the dopamine receptor",

abstract = "Fluorine-18-labeled haloperidol and spiroperidol have been prepared by an exchange reaction using the corresponding non-labeled compound or the nitro analog. Studies in rats have shown that the distribution of labeled spiroperidol has a high striatum to cerebellum ratio which is not observed with haloperidol. A ratio of 10.66 ± 1.6 is obtained two hours after administration of the 18F-spiroperidol. When 18F-spiroperidol was administered to a baboon and tomographic images obtained, the dopamine receptor rich areas were clearly visualized two hours after administration.",

author = "Welch, {Michael J.} and Kilbourn, {Michael R.} and Mathias, {Carla J.} and Mintun, {Mark A.} and Raichle, {Marcus E.}",

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AU - Mathias, Carla J.

AU - Mintun, Mark A.

AU - Raichle, Marcus E.

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