Comparison in animal models of 18F-spiroperidol and 18F-haloperidol: Potential agents for imaging the dopamine receptor

Michael J. Welch; Michael R. Kilbourn; Carla J. Mathias; Mark A. Mintun; Marcus E. Raichle

doi:10.1016/0024-3205(83)90725-7

Comparison in animal models of ¹⁸F-spiroperidol and ¹⁸F-haloperidol: Potential agents for imaging the dopamine receptor

Michael J. Welch, Michael R. Kilbourn, Carla J. Mathias, Mark A. Mintun, Marcus E. Raichle

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Abstract

Fluorine-18-labeled haloperidol and spiroperidol have been prepared by an exchange reaction using the corresponding non-labeled compound or the nitro analog. Studies in rats have shown that the distribution of labeled spiroperidol has a high striatum to cerebellum ratio which is not observed with haloperidol. A ratio of 10.66 ± 1.6 is obtained two hours after administration of the ¹⁸F-spiroperidol. When ¹⁸F-spiroperidol was administered to a baboon and tomographic images obtained, the dopamine receptor rich areas were clearly visualized two hours after administration.

Original language	English
Pages (from-to)	1687-1693
Number of pages	7
Journal	Life Sciences
Volume	33
Issue number	17
DOIs	https://doi.org/10.1016/0024-3205(83)90725-7
State	Published - Oct 24 1983

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title = "Comparison in animal models of 18F-spiroperidol and 18F-haloperidol: Potential agents for imaging the dopamine receptor",

abstract = "Fluorine-18-labeled haloperidol and spiroperidol have been prepared by an exchange reaction using the corresponding non-labeled compound or the nitro analog. Studies in rats have shown that the distribution of labeled spiroperidol has a high striatum to cerebellum ratio which is not observed with haloperidol. A ratio of 10.66 ± 1.6 is obtained two hours after administration of the 18F-spiroperidol. When 18F-spiroperidol was administered to a baboon and tomographic images obtained, the dopamine receptor rich areas were clearly visualized two hours after administration.",

author = "Welch, {Michael J.} and Kilbourn, {Michael R.} and Mathias, {Carla J.} and Mintun, {Mark A.} and Raichle, {Marcus E.}",

note = "Funding Information: This research was supported by NIH grants HL13851, NS06833, The authors thank the staff of the Washington University School of Medicine cyclotron as well as Carmen Dence for their assistance.",

year = "1983",

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doi = "10.1016/0024-3205(83)90725-7",

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T1 - Comparison in animal models of 18F-spiroperidol and 18F-haloperidol

T2 - Potential agents for imaging the dopamine receptor

AU - Welch, Michael J.

AU - Kilbourn, Michael R.

AU - Mathias, Carla J.

AU - Mintun, Mark A.

AU - Raichle, Marcus E.

N1 - Funding Information: This research was supported by NIH grants HL13851, NS06833, The authors thank the staff of the Washington University School of Medicine cyclotron as well as Carmen Dence for their assistance.

PY - 1983/10/24

Y1 - 1983/10/24

N2 - Fluorine-18-labeled haloperidol and spiroperidol have been prepared by an exchange reaction using the corresponding non-labeled compound or the nitro analog. Studies in rats have shown that the distribution of labeled spiroperidol has a high striatum to cerebellum ratio which is not observed with haloperidol. A ratio of 10.66 ± 1.6 is obtained two hours after administration of the 18F-spiroperidol. When 18F-spiroperidol was administered to a baboon and tomographic images obtained, the dopamine receptor rich areas were clearly visualized two hours after administration.

AB - Fluorine-18-labeled haloperidol and spiroperidol have been prepared by an exchange reaction using the corresponding non-labeled compound or the nitro analog. Studies in rats have shown that the distribution of labeled spiroperidol has a high striatum to cerebellum ratio which is not observed with haloperidol. A ratio of 10.66 ± 1.6 is obtained two hours after administration of the 18F-spiroperidol. When 18F-spiroperidol was administered to a baboon and tomographic images obtained, the dopamine receptor rich areas were clearly visualized two hours after administration.

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AN - SCOPUS:0020507692

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Comparison in animal models of ¹⁸F-spiroperidol and ¹⁸F-haloperidol: Potential agents for imaging the dopamine receptor

Abstract

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