TY - JOUR
T1 - Comparison between proton boron fusion therapy (PBFT) and boron neutron capture therapy (BNCT)
T2 - A monte carlo study
AU - Jung, Joo Young
AU - Yoon, Do Kun
AU - Barraclough, Brendan
AU - Lee, Heui Chang
AU - Suh, Tae Suk
AU - Lu, Bo
N1 - Funding Information:
The authors wish to thank Hye-Been Kim for illustrating figures in this study. This work was supported by the Global Ph.D. Fellowship (Grant No. 2015H1A2A1034071) and Mid-Career Researcher Program (2014R1A2A1A10050270) and Rising Career Research Program (2016R1C1B2009258) through the National Research Foundation of Korea funded by the Ministry of Science, ICT & Future Planning, Republic of Korea.
Publisher Copyright:
© Jung et al.
PY - 2017
Y1 - 2017
N2 - The aim of this study is to compare between proton boron fusion therapy (PBFT) and boron neutron capture therapy (BNCT) and to analyze dose escalation using a Monte Carlo simulation. We simulated a proton beam passing through the water with a boron uptake region (BUR) in MCNPX. To estimate the interaction between neutrons/ protons and borons by the alpha particle, the simulation yielded with a variation of the center of the BUR location and proton energies. The variation and influence about the alpha particle were observed from the percent depth dose (PDD) and cross-plane dose profile of both the neutron and proton beams. The peak value of the maximum dose level when the boron particle was accurately labeled at the region was 192.4% among the energies. In all, we confirmed that prompt gamma rays of 478 keV and 719 keV were generated by the nuclear reactions in PBFT and BNCT, respectively. We validated the dramatic effectiveness of the alpha particle, especially in PBFT. The utility of PBFT was verified using the simulation and it has a potential for application in radiotherapy.
AB - The aim of this study is to compare between proton boron fusion therapy (PBFT) and boron neutron capture therapy (BNCT) and to analyze dose escalation using a Monte Carlo simulation. We simulated a proton beam passing through the water with a boron uptake region (BUR) in MCNPX. To estimate the interaction between neutrons/ protons and borons by the alpha particle, the simulation yielded with a variation of the center of the BUR location and proton energies. The variation and influence about the alpha particle were observed from the percent depth dose (PDD) and cross-plane dose profile of both the neutron and proton beams. The peak value of the maximum dose level when the boron particle was accurately labeled at the region was 192.4% among the energies. In all, we confirmed that prompt gamma rays of 478 keV and 719 keV were generated by the nuclear reactions in PBFT and BNCT, respectively. We validated the dramatic effectiveness of the alpha particle, especially in PBFT. The utility of PBFT was verified using the simulation and it has a potential for application in radiotherapy.
KW - Boron neutron capture therapy
KW - Bragg-peak
KW - Monte carlo simulation
KW - Proton boron fusion therapy
UR - http://www.scopus.com/inward/record.url?scp=85020686522&partnerID=8YFLogxK
U2 - 10.18632/oncotarget.15700
DO - 10.18632/oncotarget.15700
M3 - Article
C2 - 28427153
AN - SCOPUS:85020686522
SN - 1949-2553
VL - 8
SP - 39774
EP - 39781
JO - Oncotarget
JF - Oncotarget
IS - 24
ER -