TY - JOUR
T1 - Comparing Survival Outcomes of Patients With LI-RADS-M Hepatocellular Carcinomas and Intrahepatic Cholangiocarcinomas
AU - Kierans, Andrea S.
AU - Lafata, Kyle J.
AU - Ludwig, Daniel R.
AU - Burke, Lauren M.B.
AU - Chernyak, Victoria
AU - Fowler, Kathryn J.
AU - Fraum, Tyler J.
AU - McGinty, Katrina A.
AU - McInnes, Matthew D.F.
AU - Mendiratta-Lala, Mishal
AU - Cunha, Guilherme Moura
AU - Allen, Brian C.
AU - Hecht, Elizabeth M.
AU - Jaffe, Tracy A.
AU - Kalisz, Kevin R.
AU - Ranathunga, Damithri S.
AU - Wildman-Tobriner, Benjamin
AU - Cardona, Diana M.
AU - Aslam, Anum
AU - Gaur, Sonia
AU - Bashir, Mustafa R.
N1 - Publisher Copyright:
© 2022 International Society for Magnetic Resonance in Medicine.
PY - 2023/1
Y1 - 2023/1
N2 - Background: There is a sparsity of data evaluating outcomes of patients with Liver Imaging Reporting and Data System (LI-RADS) (LR)-M lesions. Purpose: To compare overall survival (OS) and progression free survival (PFS) between hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA) meeting LR-M criteria and to evaluate factors associated with prognosis. Study Type: Retrospective. Subjects: Patients at risk for HCC with at least one LR-M lesion with histologic diagnosis, from 8 academic centers, yielding 120 patients with 120 LR-M lesions (84 men [mean age 62 years] and 36 women [mean age 66 years]). Field Strength/Sequence: A 1.5 and 3.0 T/3D T1-weighted gradient echo, T2-weighted fast spin-echo. Assessment: The imaging categorization of each lesion as LR-M was made clinically by a single radiologist at each site and patient outcome measures were collected. Statistical Tests: OS, PFS, and potential independent predictors were evaluated by Kaplan–Meier method, log-rank test, and Cox proportional hazard model. A P value of <0.05 was considered significant. Results: A total of 120 patients with 120 LR-M lesions were included; on histology 65 were HCC and 55 were iCCA. There was similar median OS for patients with LR-M HCC compared to patients with iCCA (738 days vs. 769 days, P = 0.576). There were no significant differences between patients with HCC and iCCA in terms of sex (47:18 vs. 37:18, P = 0.549), age (63.0 ± 8.4 vs. 63.4 ± 7.8, P = 0.847), etiology of liver disease (P = 0.202), presence of cirrhosis (100% vs. 100%, P = 1.000), tumor size (4.73 ± 3.28 vs. 4.75 ± 2.58, P = 0.980), method of lesion histologic diagnosis (P = 0.646), and proportion of patients who underwent locoregional therapy (60.0% vs. 38.2%, P = 0.100) or surgery (134.8 ± 165.5 vs. 142.5 ± 205.6, P = 0.913). Using multivariable analysis, nonsurgical compared to surgical management (HR, 4.58), larger tumor size (HR, 1.19), and higher MELD score (HR, 1.12) were independently associated with worse OS. Data Conclusion: There was similar OS in patients with LR-M HCC and LR-M iCCA, suggesting that LR-M imaging features may more closely reflect patient outcomes than histology. Evidence Level: 3. Technical Efficacy: Stage 5.
AB - Background: There is a sparsity of data evaluating outcomes of patients with Liver Imaging Reporting and Data System (LI-RADS) (LR)-M lesions. Purpose: To compare overall survival (OS) and progression free survival (PFS) between hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA) meeting LR-M criteria and to evaluate factors associated with prognosis. Study Type: Retrospective. Subjects: Patients at risk for HCC with at least one LR-M lesion with histologic diagnosis, from 8 academic centers, yielding 120 patients with 120 LR-M lesions (84 men [mean age 62 years] and 36 women [mean age 66 years]). Field Strength/Sequence: A 1.5 and 3.0 T/3D T1-weighted gradient echo, T2-weighted fast spin-echo. Assessment: The imaging categorization of each lesion as LR-M was made clinically by a single radiologist at each site and patient outcome measures were collected. Statistical Tests: OS, PFS, and potential independent predictors were evaluated by Kaplan–Meier method, log-rank test, and Cox proportional hazard model. A P value of <0.05 was considered significant. Results: A total of 120 patients with 120 LR-M lesions were included; on histology 65 were HCC and 55 were iCCA. There was similar median OS for patients with LR-M HCC compared to patients with iCCA (738 days vs. 769 days, P = 0.576). There were no significant differences between patients with HCC and iCCA in terms of sex (47:18 vs. 37:18, P = 0.549), age (63.0 ± 8.4 vs. 63.4 ± 7.8, P = 0.847), etiology of liver disease (P = 0.202), presence of cirrhosis (100% vs. 100%, P = 1.000), tumor size (4.73 ± 3.28 vs. 4.75 ± 2.58, P = 0.980), method of lesion histologic diagnosis (P = 0.646), and proportion of patients who underwent locoregional therapy (60.0% vs. 38.2%, P = 0.100) or surgery (134.8 ± 165.5 vs. 142.5 ± 205.6, P = 0.913). Using multivariable analysis, nonsurgical compared to surgical management (HR, 4.58), larger tumor size (HR, 1.19), and higher MELD score (HR, 1.12) were independently associated with worse OS. Data Conclusion: There was similar OS in patients with LR-M HCC and LR-M iCCA, suggesting that LR-M imaging features may more closely reflect patient outcomes than histology. Evidence Level: 3. Technical Efficacy: Stage 5.
KW - HCC
KW - LI-RADS M
KW - MRI
KW - overall survival
KW - progression free survival
UR - http://www.scopus.com/inward/record.url?scp=85129332021&partnerID=8YFLogxK
U2 - 10.1002/jmri.28218
DO - 10.1002/jmri.28218
M3 - Article
C2 - 35512243
AN - SCOPUS:85129332021
SN - 1053-1807
VL - 57
SP - 308
EP - 317
JO - Journal of Magnetic Resonance Imaging
JF - Journal of Magnetic Resonance Imaging
IS - 1
ER -