Comparative Genomic Profiling of Matched Primary and Metastatic Tumors in Renal Cell Carcinoma

Maria F. Becerra; Ed Reznik; Almedina Redzematovic; Daniel M. Tennenbaum; Mahyar Kashan; Mazyar Ghanaat; Jozefina Casuscelli; Brandon Manley; Philip Jonsson; Renzo G. DiNatale; Kyle A. Blum; Jeremy C. Durack; Stephen B. Solomon; Maria E. Arcila; Caitlin Bourque; Nick Socci; Maria I. Carlo; Chung Han Lee; Martin H. Voss; Darren R. Feldman; Robert J. Motzer; Jonathan A. Coleman; Paul Russo; Emily H. Cheng; A. Ari Hakimi; James J. Hsieh

doi:10.1016/j.euf.2017.09.016

Comparative Genomic Profiling of Matched Primary and Metastatic Tumors in Renal Cell Carcinoma

Maria F. Becerra
, Ed Reznik
, Almedina Redzematovic
, Daniel M. Tennenbaum
, Mahyar Kashan
, Mazyar Ghanaat
, Jozefina Casuscelli
, Brandon Manley
, Philip Jonsson
, Renzo G. DiNatale
, Kyle A. Blum
, Jeremy C. Durack
, Stephen B. Solomon
, Maria E. Arcila
, Caitlin Bourque
, Nick Socci
, Maria I. Carlo
, Chung Han Lee
, Martin H. Voss
, Darren R. Feldman

Robert J. Motzer, Jonathan A. Coleman, Paul Russo, Emily H. Cheng, A. Ari Hakimi, James J. Hsieh

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Using next-generation sequencing, we determined mutation discordance for cancer genes between matched primary and metastatic tumor samples from patients with renal cell carcinoma. As most precision cancer medicine administers targeted agents on the basis of mutations detected in primary tumors, further investigation into the genomic discordance between primary and metastatic tumor pairs is warranted.

Original language	English
Pages (from-to)	986-994
Number of pages	9
Journal	European Urology Focus
Volume	4
Issue number	6
DOIs	https://doi.org/10.1016/j.euf.2017.09.016
State	Published - Dec 2018

Keywords

Convergent evolution
Discordance
Genomics
Metastasis
Next-generation sequencing
Primary-metastasis tumor pairs
Renal cell carcinoma
Spatiotemporal divergence

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10.1016/j.euf.2017.09.016

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Becerra, M. F., Reznik, E., Redzematovic, A., Tennenbaum, D. M., Kashan, M., Ghanaat, M., Casuscelli, J., Manley, B., Jonsson, P., DiNatale, R. G., Blum, K. A., Durack, J. C., Solomon, S. B., Arcila, M. E., Bourque, C., Socci, N., Carlo, M. I., Lee, C. H., Voss, M. H., ... Hsieh, J. J. (2018). Comparative Genomic Profiling of Matched Primary and Metastatic Tumors in Renal Cell Carcinoma. European Urology Focus, 4(6), 986-994. https://doi.org/10.1016/j.euf.2017.09.016

@article{330816d519604e8c8505cc5e07f75a5b,

title = "Comparative Genomic Profiling of Matched Primary and Metastatic Tumors in Renal Cell Carcinoma",

abstract = "Using next-generation sequencing, we determined mutation discordance for cancer genes between matched primary and metastatic tumor samples from patients with renal cell carcinoma. As most precision cancer medicine administers targeted agents on the basis of mutations detected in primary tumors, further investigation into the genomic discordance between primary and metastatic tumor pairs is warranted.",

keywords = "Convergent evolution, Discordance, Genomics, Metastasis, Next-generation sequencing, Primary-metastasis tumor pairs, Renal cell carcinoma, Spatiotemporal divergence",

author = "Becerra, \{Maria F.\} and Ed Reznik and Almedina Redzematovic and Tennenbaum, \{Daniel M.\} and Mahyar Kashan and Mazyar Ghanaat and Jozefina Casuscelli and Brandon Manley and Philip Jonsson and DiNatale, \{Renzo G.\} and Blum, \{Kyle A.\} and Durack, \{Jeremy C.\} and Solomon, \{Stephen B.\} and Arcila, \{Maria E.\} and Caitlin Bourque and Nick Socci and Carlo, \{Maria I.\} and Lee, \{Chung Han\} and Voss, \{Martin H.\} and Feldman, \{Darren R.\} and Motzer, \{Robert J.\} and Coleman, \{Jonathan A.\} and Paul Russo and Cheng, \{Emily H.\} and Hakimi, \{A. Ari\} and Hsieh, \{James J.\}",

note = "Publisher Copyright: {\textcopyright} 2017 European Association of Urology",

year = "2018",

month = dec,

doi = "10.1016/j.euf.2017.09.016",

language = "English",

volume = "4",

pages = "986--994",

journal = "European Urology Focus",

issn = "2405-4569",

number = "6",

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Becerra, MF, Reznik, E, Redzematovic, A, Tennenbaum, DM, Kashan, M, Ghanaat, M, Casuscelli, J, Manley, B, Jonsson, P, DiNatale, RG, Blum, KA, Durack, JC, Solomon, SB, Arcila, ME, Bourque, C, Socci, N, Carlo, MI, Lee, CH, Voss, MH, Feldman, DR, Motzer, RJ, Coleman, JA, Russo, P, Cheng, EH, Hakimi, AA & Hsieh, JJ 2018, 'Comparative Genomic Profiling of Matched Primary and Metastatic Tumors in Renal Cell Carcinoma', European Urology Focus, vol. 4, no. 6, pp. 986-994. https://doi.org/10.1016/j.euf.2017.09.016

TY - JOUR

T1 - Comparative Genomic Profiling of Matched Primary and Metastatic Tumors in Renal Cell Carcinoma

AU - Becerra, Maria F.

AU - Reznik, Ed

AU - Redzematovic, Almedina

AU - Tennenbaum, Daniel M.

AU - Kashan, Mahyar

AU - Ghanaat, Mazyar

AU - Casuscelli, Jozefina

AU - Manley, Brandon

AU - Jonsson, Philip

AU - DiNatale, Renzo G.

AU - Blum, Kyle A.

AU - Durack, Jeremy C.

AU - Solomon, Stephen B.

AU - Arcila, Maria E.

AU - Bourque, Caitlin

AU - Socci, Nick

AU - Carlo, Maria I.

AU - Lee, Chung Han

AU - Voss, Martin H.

AU - Feldman, Darren R.

AU - Motzer, Robert J.

AU - Coleman, Jonathan A.

AU - Russo, Paul

AU - Cheng, Emily H.

AU - Hakimi, A. Ari

AU - Hsieh, James J.

PY - 2018/12

Y1 - 2018/12

N2 - Using next-generation sequencing, we determined mutation discordance for cancer genes between matched primary and metastatic tumor samples from patients with renal cell carcinoma. As most precision cancer medicine administers targeted agents on the basis of mutations detected in primary tumors, further investigation into the genomic discordance between primary and metastatic tumor pairs is warranted.

AB - Using next-generation sequencing, we determined mutation discordance for cancer genes between matched primary and metastatic tumor samples from patients with renal cell carcinoma. As most precision cancer medicine administers targeted agents on the basis of mutations detected in primary tumors, further investigation into the genomic discordance between primary and metastatic tumor pairs is warranted.

KW - Convergent evolution

KW - Discordance

KW - Genomics

KW - Metastasis

KW - Next-generation sequencing

KW - Primary-metastasis tumor pairs

KW - Renal cell carcinoma

KW - Spatiotemporal divergence

UR - https://www.scopus.com/pages/publications/85031743164

U2 - 10.1016/j.euf.2017.09.016

DO - 10.1016/j.euf.2017.09.016

M3 - Article

C2 - 29066084

AN - SCOPUS:85031743164

SN - 2405-4569

VL - 4

SP - 986

EP - 994

JO - European Urology Focus

JF - European Urology Focus

IS - 6

ER -

Comparative Genomic Profiling of Matched Primary and Metastatic Tumors in Renal Cell Carcinoma

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