@article{330816d519604e8c8505cc5e07f75a5b,
title = "Comparative Genomic Profiling of Matched Primary and Metastatic Tumors in Renal Cell Carcinoma",
abstract = "Using next-generation sequencing, we determined mutation discordance for cancer genes between matched primary and metastatic tumor samples from patients with renal cell carcinoma. As most precision cancer medicine administers targeted agents on the basis of mutations detected in primary tumors, further investigation into the genomic discordance between primary and metastatic tumor pairs is warranted.",
keywords = "Convergent evolution, Discordance, Genomics, Metastasis, Next-generation sequencing, Primary-metastasis tumor pairs, Renal cell carcinoma, Spatiotemporal divergence",
author = "Becerra, {Maria F.} and Ed Reznik and Almedina Redzematovic and Tennenbaum, {Daniel M.} and Mahyar Kashan and Mazyar Ghanaat and Jozefina Casuscelli and Brandon Manley and Philip Jonsson and DiNatale, {Renzo G.} and Blum, {Kyle A.} and Durack, {Jeremy C.} and Solomon, {Stephen B.} and Arcila, {Maria E.} and Caitlin Bourque and Nick Socci and Carlo, {Maria I.} and Lee, {Chung Han} and Voss, {Martin H.} and Feldman, {Darren R.} and Motzer, {Robert J.} and Coleman, {Jonathan A.} and Paul Russo and Cheng, {Emily H.} and Hakimi, {A. Ari} and Hsieh, {James J.}",
note = "Funding Information: Other: None. Financial disclosures: James J. Hsieh certifies that all conflicts of interest, including specific financial interests and relationships and affiliations relevant to the subject matter or materials discussed in the manuscript (eg, employment/affiliation, grants or funding, consultancies, honoraria, stock ownership or options, expert testimony, royalties, or patents filed, received, or pending), are the following: None. Funding/Support and role of the sponsor : This work and James J. Hsieh were supported by the J. Randall and Kathleen L. MacDonald Family Research Fund and the Jill and Jeffrey Weiss Family Fund for the cure of metastatic kidney cancer. This work was supported in part by the Sidney Kimmel Center for Prostate and Urologic Cancers and NIH/NCI Cancer Center support grant P30 CA008748 . Robert J. Motzer and Mazyar Ghanaat were supported by Ruth L. Kirschstein National Research Service award T3to2CA082088. Jozefina Casuscelli was supported by German Research Foundation grant CA1403/1-1 . Maria I. Carlo was supported by a Kidney Cancer Association Young Investigator Award. The sponsors played no direct role in the study. Publisher Copyright: {\textcopyright} 2017 European Association of Urology",
year = "2018",
month = dec,
doi = "10.1016/j.euf.2017.09.016",
language = "English",
volume = "4",
pages = "986--994",
journal = "European Urology Focus",
issn = "2405-4569",
number = "6",
}