Comparative Genomic Profiling of Matched Primary and Metastatic Tumors in Renal Cell Carcinoma

Maria F. Becerra, Ed Reznik, Almedina Redzematovic, Daniel M. Tennenbaum, Mahyar Kashan, Mazyar Ghanaat, Jozefina Casuscelli, Brandon Manley, Philip Jonsson, Renzo G. DiNatale, Kyle A. Blum, Jeremy C. Durack, Stephen B. Solomon, Maria E. Arcila, Caitlin Bourque, Nick Socci, Maria I. Carlo, Chung Han Lee, Martin H. Voss, Darren R. FeldmanRobert J. Motzer, Jonathan A. Coleman, Paul Russo, Emily H. Cheng, A. Ari Hakimi, James J. Hsieh

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Using next-generation sequencing, we determined mutation discordance for cancer genes between matched primary and metastatic tumor samples from patients with renal cell carcinoma. As most precision cancer medicine administers targeted agents on the basis of mutations detected in primary tumors, further investigation into the genomic discordance between primary and metastatic tumor pairs is warranted.

Original languageEnglish
Pages (from-to)986-994
Number of pages9
JournalEuropean Urology Focus
Volume4
Issue number6
DOIs
StatePublished - Dec 2018

Keywords

  • Convergent evolution
  • Discordance
  • Genomics
  • Metastasis
  • Next-generation sequencing
  • Primary-metastasis tumor pairs
  • Renal cell carcinoma
  • Spatiotemporal divergence

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