@article{330816d519604e8c8505cc5e07f75a5b,
title = "Comparative Genomic Profiling of Matched Primary and Metastatic Tumors in Renal Cell Carcinoma",
abstract = "Using next-generation sequencing, we determined mutation discordance for cancer genes between matched primary and metastatic tumor samples from patients with renal cell carcinoma. As most precision cancer medicine administers targeted agents on the basis of mutations detected in primary tumors, further investigation into the genomic discordance between primary and metastatic tumor pairs is warranted.",
keywords = "Convergent evolution, Discordance, Genomics, Metastasis, Next-generation sequencing, Primary-metastasis tumor pairs, Renal cell carcinoma, Spatiotemporal divergence",
author = "Becerra, {Maria F.} and Ed Reznik and Almedina Redzematovic and Tennenbaum, {Daniel M.} and Mahyar Kashan and Mazyar Ghanaat and Jozefina Casuscelli and Brandon Manley and Philip Jonsson and DiNatale, {Renzo G.} and Blum, {Kyle A.} and Durack, {Jeremy C.} and Solomon, {Stephen B.} and Arcila, {Maria E.} and Caitlin Bourque and Nick Socci and Carlo, {Maria I.} and Lee, {Chung Han} and Voss, {Martin H.} and Feldman, {Darren R.} and Motzer, {Robert J.} and Coleman, {Jonathan A.} and Paul Russo and Cheng, {Emily H.} and Hakimi, {A. Ari} and Hsieh, {James J.}",
note = "Publisher Copyright: {\textcopyright} 2017 European Association of Urology",
year = "2018",
month = dec,
doi = "10.1016/j.euf.2017.09.016",
language = "English",
volume = "4",
pages = "986--994",
journal = "European Urology Focus",
issn = "2405-4569",
number = "6",
}