@article{4d18de358ae349f4b94c90494ea9ac5e,
title = "Comparative Analysis and Refinement of Human PSC-Derived Kidney Organoid Differentiation with Single-Cell Transcriptomics",
abstract = "A strong characterization of cell types, lineages, and differentiation states present in human PSC-derived kidney organoids is critical to improve differentiation protocols. Wu et al. use single-cell transcriptomics to reveal non-renal cell types, describe lineage-specific expression of regulatory genes, and report a broadly applicable strategy to reduce off-target cell populations.",
keywords = "BDNF signaling, Dropseq, human kidney, induced pluripotent stem cells, kidney organoid, off-target cells, single cell RNA-seq, stem cell differentiation",
author = "Haojia Wu and Kohei Uchimura and Donnelly, {Erinn L.} and Yuhei Kirita and Morris, {Samantha A.} and Humphreys, {Benjamin D.}",
note = "Funding Information: This work was supported by NIH/NIDDK grants DK103740 and DK107374 , an established investigator award of the American Heart Association , and grant 173970 from the Chan Zuckerberg Initiative (all to B.D.H.). K.U. was supported by Japan Society for the Promotion of Science postdoctoral fellowships for research abroad. Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",
year = "2018",
month = dec,
day = "6",
doi = "10.1016/j.stem.2018.10.010",
language = "English",
volume = "23",
pages = "869--881.e8",
journal = "Cell Stem Cell",
issn = "1934-5909",
number = "6",
}