Comparable survival after HLA-well-matched unrelated or matched sibling donor transplantation for acute myeloid leukemia in first remission with unfavorable cytogenetics at diagnosis

Vikas Gupta, Martin S. Tallman, Wensheng He, Brent R. Logan, Edward Copelan, Robert Peter Gale, Hanna J. Khoury, Thomas Klumpp, John Koreth, Hillard M. Lazarus, David I. Marks, Rodrigo Martino, David A. Rizzieri, Jacob M. Rowe, Mitchell Sabloff, Edmund K. Waller, John F. DiPersio, Donald W. Bunjes, Daniel J. Weisdorf

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130 Scopus citations

Abstract

We compared the outcomes of unrelated donor (URD, n = 358) with human leukocyte antigen (HLA) - matched sibling donor (MSD, n = 226) transplantations in patients with acute myeloid leukemia (AML) in first complete remission (CR1) having unfavorable cytogenetics at diagnosis. Unfavorable cytogenetic abnormalities were: complex (≥ 3 abnormalities), 32%; and noncomplex involving chromosome 7, 25%; chromosome 5, 9%; 11q or MLL rearrangements, 18%; t(6;9), 5%; and other noncomplex, 10%. URDs were HLA-well-matched (n = 254; 71%) or partially-matched (n = 104; 29%). Three-year leukemia-free survival (LFS) for MSD was 42% (95% confidence interval [CI], 35%-48%) compared with 34% (95% CI, 28%-41%) for HLA-well-matched URD and 29%(95% CI, 20%-39%) for partially-matched URD (P = .08). In multivariate analysis, HLA-well-matched URD and MSD yielded similar LFS (relative risk [RR] = 1.1, 95% CI, 0.86-1.40, P = .44) and overall survival (OS; RR = 1.06, 95% CI, 0.83-1.37, P = .63). LFS and OS were significantly inferior for HLA-partially-matched URD recipients, those with prior myelodysplastic syndrome, and those older than 50 years. All cytogenetic cohorts had similar outcomes. Patients with chronic graft-versus-host disease had a significantly lower risk of relapse (RR = 0.68, 95% CI, 0.47-0.99, P = .05). Hematopoietic cell transplantation (HCT) using HLA-well-matched URD and MSD resulted in similar LFS and OS in AML patients in CR1 with unfavorable cytogenetics. Outcomes of HCT from HLA-partially-matched URD were inferior.

Original languageEnglish
Pages (from-to)1839-1848
Number of pages10
JournalBlood
Volume116
Issue number11
DOIs
StatePublished - Sep 16 2010

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    Gupta, V., Tallman, M. S., He, W., Logan, B. R., Copelan, E., Gale, R. P., Khoury, H. J., Klumpp, T., Koreth, J., Lazarus, H. M., Marks, D. I., Martino, R., Rizzieri, D. A., Rowe, J. M., Sabloff, M., Waller, E. K., DiPersio, J. F., Bunjes, D. W., & Weisdorf, D. J. (2010). Comparable survival after HLA-well-matched unrelated or matched sibling donor transplantation for acute myeloid leukemia in first remission with unfavorable cytogenetics at diagnosis. Blood, 116(11), 1839-1848. https://doi.org/10.1182/blood-2010-04-278317