TY - JOUR
T1 - Comparable performance of the kansas city cardiomyopathy questionnaire in patients with heart failure with preserved and reduced ejection fraction
AU - Joseph, Susan M.
AU - Novak, Eric
AU - Arnold, Suzanne V.
AU - Jones, Philip G.
AU - Khattak, Himad
AU - Platts, Anne E.
AU - Davila-Roman, Victor G.
AU - Mann, Douglas L.
AU - Spertus, John A.
PY - 2013/11
Y1 - 2013/11
N2 - Background.Despite the growing epidemic of heart failure with preserved ejection fraction (HFpEF), no valid measure of patients f health status (symptoms, function, and quality of life) exists. We evaluated the Kansas City Cardiomyopathy Questionnaire (KCCQ), a validated measure of HF with reduced EF, in patients with HFpEF. Methods and Results.Using a prospective HF registry, we dichotomized patients into HF with reduced EF (EF. 40) and HFpEF (EF.50). The associations between New York Heart Association class, a commonly used criterion standard, and KCCQ Overall Summary and Total Symptom domains were evaluated using Spearman correlations and 2-way ANOVA with differences between patients with HF with reduced EF and HFpEF tested with interaction terms. Predictive validity of the KCCQ Overall Summary scores was assessed with Kaplan.Meier curves for death and all-cause hospitalization. Covariate adjustment was made using Cox proportional hazards models. Internal reliability was assessed with Cronbach fs ¿. Among 849 patients, 200 (24%) had HFpEF. KCCQ summary scores were strongly associated with New York Heart Association class in both patients with HFpEF (r=.0.62; P<0.001) and HF with reduced EF (r=.0.55; P=0.27 for interaction). One-year event-free rates by KCCQ category among patients with HFpEF were 0 to 25=13.8%, 26 to 50=59.1%, 51 to 75=73.8%, and 76 to 100=77.8% (log rank P<0.001), with no significant interaction by EF (P=0.37). The KCCQ domains demonstrated high internal consistency among patients with HFpEF (Cronbach fs ¿=0.96 for overall summary and .0.69 in all subdomains). Conclusions.Among patients with HFpEF, the KCCQ seems to be a valid and reliable measure of health status and offers excellent prognostic ability. Future studies should extend and replicate our findings, including the establishment of its responsiveness to clinical change.
AB - Background.Despite the growing epidemic of heart failure with preserved ejection fraction (HFpEF), no valid measure of patients f health status (symptoms, function, and quality of life) exists. We evaluated the Kansas City Cardiomyopathy Questionnaire (KCCQ), a validated measure of HF with reduced EF, in patients with HFpEF. Methods and Results.Using a prospective HF registry, we dichotomized patients into HF with reduced EF (EF. 40) and HFpEF (EF.50). The associations between New York Heart Association class, a commonly used criterion standard, and KCCQ Overall Summary and Total Symptom domains were evaluated using Spearman correlations and 2-way ANOVA with differences between patients with HF with reduced EF and HFpEF tested with interaction terms. Predictive validity of the KCCQ Overall Summary scores was assessed with Kaplan.Meier curves for death and all-cause hospitalization. Covariate adjustment was made using Cox proportional hazards models. Internal reliability was assessed with Cronbach fs ¿. Among 849 patients, 200 (24%) had HFpEF. KCCQ summary scores were strongly associated with New York Heart Association class in both patients with HFpEF (r=.0.62; P<0.001) and HF with reduced EF (r=.0.55; P=0.27 for interaction). One-year event-free rates by KCCQ category among patients with HFpEF were 0 to 25=13.8%, 26 to 50=59.1%, 51 to 75=73.8%, and 76 to 100=77.8% (log rank P<0.001), with no significant interaction by EF (P=0.37). The KCCQ domains demonstrated high internal consistency among patients with HFpEF (Cronbach fs ¿=0.96 for overall summary and .0.69 in all subdomains). Conclusions.Among patients with HFpEF, the KCCQ seems to be a valid and reliable measure of health status and offers excellent prognostic ability. Future studies should extend and replicate our findings, including the establishment of its responsiveness to clinical change.
KW - Health status
KW - Heart failure diastolic
KW - Quality of life
UR - http://www.scopus.com/inward/record.url?scp=84892656686&partnerID=8YFLogxK
U2 - 10.1161/CIRCHEARTFAILURE.113.000359
DO - 10.1161/CIRCHEARTFAILURE.113.000359
M3 - Article
C2 - 24130003
AN - SCOPUS:84892656686
SN - 1941-3289
VL - 6
SP - 1139
EP - 1146
JO - Circulation: Heart Failure
JF - Circulation: Heart Failure
IS - 6
ER -